SYRE
Spyre Therapeutics Inc.
NASDAQ: SYRE · HEALTHCARE · BIOTECHNOLOGY
$76.43
-6.15% today
Updated 2026-06-05
Market cap
$7.02B
P/E ratio
—
P/S ratio
650.22x
EPS (TTM)
$-2.12
Dividend yield
—
52W range
$14 – $84
Volume
1.2M
WallStSmart proprietary scores
23
out of 100
Grade: F
Strong Sell
Investment rating
3.7
Growth
D7.3
Quality
B+3.0
Profitability
D5.0
Valuation
C+3/9
Piotroski F-Score
Weak
5.0
Altman Z-Score
Safe zone
—
Industry rank
—
View all highly rated stocks (75+) →202 stocks currently score above 75
Price targets
Analyst target
$96.07
+25.70%
12-Month target
—
—
Intrinsic (DCF)
—
Margin of safety
—
0 Strong Buy17 Buy0 Hold0 Sell0 Strong Sell
Price chart
Stock snapshot
Strengths
+ Altman Z 5.01 — safe zone
Risks
- Piotroski 3/9 — weak financial health
- Thin margins at 0.00%
- Negative free cash flow $-57.54M
Key financials
Revenue Net Income Free Cash Flow
| Metric | 2022 | 2023 | 2024 | 2025 | TTM |
|---|---|---|---|---|---|
| Revenue | $2.33M | $886000.00 | $886000.00 | $0.00 | $0.00 |
| Net income | $-83.81M | $-338.79M | $-208.02M | $-155.20M | $-69.00M |
| EPS | — | — | — | — | $-2.12 |
| Free cash flow | $-80.18M | $-99.91M | $-157.41M | $-169.25M | $-57.54M |
| Profit margin | -3,598.75% | -38,238.15% | -23,478.33% | — | — |
Peer comparison
Smart narrative
Spyre Therapeutics Inc. trades at $76.43. Our Smart Value Score of 23/100 indicates the stock is weak. The company scores 3/9 on the Piotroski F-Score. With an Altman Z-Score of 5.01, it sits in the safe zone.
Frequently asked questions
What is Spyre Therapeutics Inc.'s stock price?
Spyre Therapeutics Inc. (SYRE) trades at $76.43, on a P/S of 650.2x. Those multiples show what the market is paying for each dollar of earnings and sales, which is the real starting point for judging whether the price is reasonable.
Is Spyre Therapeutics Inc. overvalued?
Spyre Therapeutics Inc. carries a Smart Value Score of 23/100 (Grade F), which we rate Strong Sell. That score blends growth, quality, and valuation into one read.
What is the price target of Spyre Therapeutics Inc. (SYRE)?
The 12-month analyst consensus target is $96.07, about 25.7% above the current $76.43. A consensus target is the average of Wall Street's 12-month forecasts, so it works as a sentiment gauge rather than a guarantee, and it resets with every earnings cycle.
Altman Z-Score?
Spyre Therapeutics Inc.'s Altman Z-Score is 5.01, which places it in the safe zone. The Altman Z-Score gauges bankruptcy risk from profitability, leverage, and asset efficiency, and a higher reading points to lower financial distress risk.
Company info
SectorHEALTHCARE
IndustryBIOTECHNOLOGY
CountryUSA
ExchangeNASDAQ
CurrencyUSD
Quick metrics
P/S ratio650.22x
ROE-26.75%
Beta3.06
50D MA$69.87
200D MA$39.51
Shares out0.09B
Float0.08B
Short ratio—
Avg volume1.2M
Performance
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YTD—
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