SYRE
Spyre Therapeutics Inc.
NASDAQ: SYRE · HEALTHCARE · BIOTECHNOLOGY
$71.89
+4.75% today
Updated 2026-04-29
Market cap
$6.20B
P/E ratio
—
P/S ratio
650.22x
EPS (TTM)
$-1.98
Dividend yield
—
52W range
$12 – $75
Volume
1.1M
Spyre Therapeutics Inc. (SYRE) Earnings
Quarterly earnings history, analyst estimates, and stock price reaction.
EPS beat streak
5 of 8
Last 8 quarters
Avg EPS surprise
+34.7%
Last 4 quarters
Revenue YoY growth
—
Most recent quarter
EPS YoY growth
+8.6%
Most recent quarter
Earnings surprise history (last 12 quarters)
Beat estimate Missed estimate
Quarterly EPS and revenue trend
Quarterly revenue EPS (diluted)
How the stock reacts to earnings
Avg 1-day reaction
-2.4%
Last 3 reports
Positive reaction rate
0%
0 of 3 quarters
Largest single-day move
-3.9%
2025-11-04
| Report date | EPS actual | Surprise | Close before | Close after | 1-day reaction |
|---|---|---|---|---|---|
| 2026-02-26 | $-0.74 | -5.1% | $43.88 | $43.01 | -2.0% |
| 2025-11-04 | $-0.15 | +80.5% | $23.78 | $22.85 | -3.9% |
| 2025-08-05 | $-0.49 | +35.0% | $16.16 | $15.96 | -1.2% |
Quarterly earnings history
| Fiscal quarter ending | EPS estimate | EPS actual | Surprise | Revenue | YoY revenue |
|---|---|---|---|---|---|
| 2025-12-31 | $-0.70 | $-0.74 | -5.1% | $90.49M | — |
| 2025-09-30 | $-0.77 | $-0.15 | +80.5% | — | — |
| 2025-06-30 | $-0.75 | $-0.49 | +35.0% | — | — |
| 2025-03-31 | $-0.84 | $-0.60 | +28.6% | — | — |
| 2024-12-31 | $-0.94 | $-0.81 | +14.2% | — | — |
| 2024-09-30 | $-0.82 | $-1.36 | -65.9% | — | — |
| 2024-06-30 | $-0.95 | $-0.86 | +9.5% | — | — |
| 2024-03-31 | $-1.17 | $-1.20 | -2.6% | — | — |
| 2023-12-31 | $-0.78 | $-4.05 | -419.2% | $1.04M | — |
| 2023-09-30 | $-0.84 | $-9.34 | -1011.9% | — | — |
| 2023-06-30 | $-3.48 | $-56.75 | -1530.7% | $688000.00 | — |
Frequently asked questions
Has Spyre Therapeutics Inc. beaten earnings estimates?
Spyre Therapeutics Inc. has beaten Wall Street EPS estimates in 5 of its last 8 quarterly reports, with an average EPS surprise of +34.7% over the last 4 quarters.
How does SYRE stock react to earnings?
SYRE stock has moved an average of -2.4% in the trading day following earnings over its last 3 reports, with positive reactions in 0% of those quarters.