SYRE
Spyre Therapeutics Inc.
NASDAQ: SYRE · HEALTHCARE · BIOTECHNOLOGY
$76.43
-6.15% today
Updated 2026-06-05
Market cap
$7.02B
P/E ratio
—
P/S ratio
650.22x
EPS (TTM)
$-2.12
Dividend yield
—
52W range
$14 – $84
Volume
1.2M
Spyre Therapeutics Inc. (SYRE) Financial statements
SEC filings — annual and quarterly data.
Income statement — annual
| Item | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | — | $6.08M | $4.63M | $5.21M | $3.89M | $0.00 | $0.00 | $18.74M | $2.33M | $886000.00 | $886000.00 | $0.00 |
| Revenue growth (YoY) | — | — | -23.9% | +12.5% | -25.3% | -100.0% | — | — | -87.6% | -62.0% | +0.0% | -100.0% |
| Cost of revenue | $19000.00 | $89000.00 | — | — | — | $901000.00 | $1.62M | $2.00M | $1.96M | $964000.00 | $964000.00 | $171.65M |
| Gross profit | $-19000.00 | $6.00M | $4.63M | $5.21M | $3.89M | $-901000.00 | $-1.62M | $18.74M | $2.33M | $-78000.00 | $886000.00 | $-171.65M |
| Gross margin | — | 98.5% | 100.0% | 100.0% | 100.0% | — | — | 100.0% | 100.0% | -8.8% | 100.0% | — |
| R&D | $6.83M | $11.45M | $18.14M | $22.82M | $36.72M | $64.60M | $59.64M | $57.07M | $58.58M | $89.50M | $162.79M | $171.65M |
| SG&A | — | $5.95M | — | — | — | $17.80M | $21.84M | $27.32M | $28.53M | $39.95M | $45.78M | $47.91M |
| Operating income | $-8.90M | $-11.31M | $-21.91M | $-27.68M | $-45.46M | $-80.33M | $-81.48M | $-65.65M | $-84.78M | $-242.30M | $-208.57M | $-209.56M |
| Operating margin | — | -185.9% | -473.3% | -531.7% | -1169.3% | — | — | -350.3% | -3640.2% | -27348.0% | -23540.2% | — |
| EBITDA | $-10.33M | $-11.23M | $-21.77M | $-27.43M | $-45.17M | $-77.35M | $-79.27M | $-64.07M | $-82.82M | $-242.30M | $-207.97M | $-209.56M |
| EBITDA margin | — | -184.5% | -470.5% | -526.9% | -1161.8% | — | — | -341.9% | -3555.9% | -27348.0% | -23472.6% | — |
| EBIT | $-10.35M | $-11.31M | $-21.91M | $-27.68M | $-45.46M | $-78.25M | $-80.89M | $-65.65M | $-84.78M | $-243.05M | $-128.56M | $-219.56M |
| Interest expense | — | — | — | — | — | — | — | — | — | — | — | — |
| Income tax | — | — | — | — | — | — | — | — | — | — | — | — |
| Effective tax rate | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Net income | $-10.35M | $-11.29M | $-21.70M | $-27.24M | $-44.35M | $-78.25M | $-80.89M | $-65.80M | $-83.81M | $-338.79M | $-208.02M | $-155.20M |
| Net income growth (YoY) | — | -9.2% | -92.1% | -25.5% | -62.8% | -76.5% | -3.4% | +18.7% | -27.4% | -304.2% | +38.6% | +25.4% |
| Profit margin | — | -185.6% | -468.8% | -523.3% | -1140.6% | — | — | -351.1% | -3598.8% | -38238.1% | -23478.3% | — |
Frequently asked questions
How much free cash flow does SYRE generate?
SYRE produced $-169.25M in free cash flow in its most recent fiscal year. Free cash flow is what is left after running and reinvesting in the business, and it is the cash that actually funds buybacks, dividends, and a stronger balance sheet.
Is SYRE's balance sheet healthy?
SYRE holds $85.72M in cash and equivalents against — in long-term debt, on $715.24M of shareholder equity. That debt is best read against the cash flow the business throws off each year.