WallStSmart
SYRE

Spyre Therapeutics Inc.

NASDAQ: SYRE · HEALTHCARE · BIOTECHNOLOGY

$71.89
+4.75% today

Updated 2026-04-29

Market cap
$6.20B
P/E ratio
P/S ratio
650.22x
EPS (TTM)
$-1.98
Dividend yield
52W range
$12 – $75
Volume
1.1M

Spyre Therapeutics Inc. (SYRE) Financial statements

SEC filings — annual and quarterly data.

Income statement — annual

Item201420152016201720182019202020212022202320242025
Revenue$6.08M$4.63M$5.21M$3.89M$0.00$0.00$18.74M$2.33M$886000.00$886000.00$0.00
Revenue growth (YoY)-23.9%+12.5%-25.3%-100.0%-87.6%-62.0%+0.0%-100.0%
Cost of revenue$19000.00$89000.00$901000.00$1.62M$2.00M$1.96M$964000.00$964000.00$171.65M
Gross profit$-19000.00$6.00M$4.63M$5.21M$3.89M$-901000.00$-1.62M$18.74M$2.33M$-78000.00$886000.00$-171.65M
Gross margin98.5%100.0%100.0%100.0%100.0%100.0%-8.8%100.0%
R&D$6.83M$11.45M$18.14M$22.82M$36.72M$64.60M$59.64M$57.07M$58.58M$89.50M$162.79M$171.65M
SG&A$5.95M$17.80M$21.84M$27.32M$28.53M$39.95M$45.78M$47.91M
Operating income$-8.90M$-11.31M$-21.91M$-27.68M$-45.46M$-80.33M$-81.48M$-65.65M$-84.78M$-242.30M$-208.57M$-209.56M
Operating margin-185.9%-473.3%-531.7%-1169.3%-350.3%-3640.2%-27348.0%-23540.2%
EBITDA$-10.33M$-11.23M$-21.77M$-27.43M$-45.17M$-77.35M$-79.27M$-64.07M$-82.82M$-242.30M$-207.97M$-209.56M
EBITDA margin-184.5%-470.5%-526.9%-1161.8%-341.9%-3555.9%-27348.0%-23472.6%
EBIT$-10.35M$-11.31M$-21.91M$-27.68M$-45.46M$-78.25M$-80.89M$-65.65M$-84.78M$-243.05M$-128.56M$-219.56M
Interest expense
Income tax
Effective tax rate0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%
Net income$-10.35M$-11.29M$-21.70M$-27.24M$-44.35M$-78.25M$-80.89M$-65.80M$-83.81M$-338.79M$-208.02M$-155.20M
Net income growth (YoY)-9.2%-92.1%-25.5%-62.8%-76.5%-3.4%+18.7%-27.4%-304.2%+38.6%+25.4%
Profit margin-185.6%-468.8%-523.3%-1140.6%-351.1%-3598.8%-38238.1%-23478.3%