IONS
Ionis Pharmaceuticals Inc
NASDAQ: IONS · HEALTHCARE · BIOTECHNOLOGY
$74.76
-0.09% today
Updated 2026-04-30
Market cap
$11.85B
P/E ratio
—
P/S ratio
12.56x
EPS (TTM)
$-2.38
Dividend yield
—
52W range
$30 – $87
Volume
2.2M
Ionis Pharmaceuticals Inc (IONS) Financial statements
SEC filings — annual and quarterly data.
Profit margin
-40.40%
Operating margin
-105.50%
ROE
-70.80%
ROA
-7.31%
Debt/equity
—
Margin trends — annual
Gross margin Operating margin Profit margin
| Year | Revenue | Net income | Gross margin | Op. margin | Profit margin |
|---|---|---|---|---|---|
| 2006 | $14.86M | $-45.90M | 165.10% | -438.91% | -308.92% |
| 2007 | $58.34M | $-10.99M | 119.33% | -56.42% | -18.84% |
| 2008 | $107.19M | $-18.17M | 100.00% | -12.18% | -16.95% |
| 2009 | $121.60M | $155.07M | 100.00% | -22.65% | 127.52% |
| 2010 | $108.47M | $-61.25M | 100.00% | -44.58% | -56.47% |
| 2011 | $99.09M | $-84.80M | 100.00% | -71.76% | -85.58% |
| 2012 | $102.05M | $-65.48M | -55.28% | -67.54% | -64.16% |
| 2013 | $147.28M | $-60.64M | -24.95% | -35.08% | -41.17% |
| 2014 | $214.16M | $-38.98M | -12.88% | -22.29% | -18.20% |
| 2015 | $283.70M | $-88.28M | -13.60% | -26.70% | -31.12% |
| 2016 | $346.62M | $-86.56M | 0.66% | -13.36% | -24.97% |
| 2017 | $514.18M | $346000.00 | 100.00% | 6.04% | 0.07% |
| 2018 | $599.67M | $273.74M | 99.70% | -10.23% | 45.65% |
| 2019 | $1.12B | $294.00M | 99.64% | 32.59% | 26.18% |
| 2020 | $729.00M | $-487.00M | 98.35% | -23.59% | -66.80% |
| 2021 | $810.46M | $-28.60M | 98.66% | -3.72% | -3.53% |
| 2022 | $587.37M | $-269.72M | 97.60% | -69.84% | -45.92% |
| 2023 | $787.65M | $-366.29M | 98.84% | -44.91% | -46.50% |
| 2024 | $705.14M | $-453.90M | 98.41% | -67.37% | -64.37% |
| 2025 | $944.00M | $-381.00M | 98.31% | -40.47% | -40.36% |