IONS
Ionis Pharmaceuticals Inc
NASDAQ: IONS · HEALTHCARE · BIOTECHNOLOGY
$74.76
-0.09% today
Updated 2026-04-30
Market cap
$11.85B
P/E ratio
—
P/S ratio
12.56x
EPS (TTM)
$-2.38
Dividend yield
—
52W range
$30 – $87
Volume
2.2M
Ionis Pharmaceuticals Inc (IONS) Financial statements
SEC filings — annual and quarterly data.
Income statement — annual
| Item | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $14.86M | $58.34M | $107.19M | $121.60M | $108.47M | $99.09M | $102.05M | $147.28M | $214.16M | $283.70M | $346.62M | $514.18M | $599.67M | $1.12B | $729.00M | $810.46M | $587.37M | $787.65M | $705.14M | $944.00M |
| Revenue growth (YoY) | — | +292.7% | +83.7% | +13.4% | -10.8% | -8.7% | +3.0% | +44.3% | +45.4% | +32.5% | +22.2% | +48.3% | +16.6% | +87.3% | -35.1% | +11.2% | -27.5% | +34.1% | -10.5% | +33.9% |
| Cost of revenue | $5.78M | $10.97M | $38.18M | $47.80M | $35.42M | $14.52M | $158.46M | $184.03M | $241.75M | $322.29M | $344.32M | $374.64M | $1.82M | $4.00M | $12.00M | $10.84M | $14.12M | $9.13M | $11.21M | $16.00M |
| Gross profit | $24.53M | $69.62M | $107.19M | $121.60M | $108.47M | $99.09M | $-56.41M | $-36.75M | $-27.59M | $-38.59M | $2.30M | $514.18M | $597.85M | $1.12B | $717.00M | $799.61M | $573.25M | $778.51M | $693.92M | $928.00M |
| Gross margin | 165.1% | 119.3% | 100.0% | 100.0% | 100.0% | 100.0% | -55.3% | -25.0% | -12.9% | -13.6% | 0.7% | 100.0% | 99.7% | 99.6% | 98.4% | 98.7% | 97.6% | 98.8% | 98.4% | 98.3% |
| R&D | $80.57M | $92.64M | $106.44M | $134.62M | $145.16M | $157.40M | $158.46M | $184.03M | $241.75M | $322.29M | $344.32M | $374.64M | $414.60M | $466.00M | $535.00M | $643.00M | $833.00M | $899.63M | $901.53M | $916.00M |
| SG&A | $12.62M | $15.93M | $13.81M | $14.52M | $11.67M | $12.79M | $12.52M | $14.92M | $20.14M | $37.17M | $48.62M | $108.49M | $244.62M | $287.00M | $354.00M | $170.90M | $150.30M | $232.60M | $267.50M | $393.90M |
| Operating income | $-65.22M | $-32.92M | $-13.06M | $-27.54M | $-48.36M | $-71.10M | $-68.92M | $-51.67M | $-47.73M | $-75.76M | $-46.32M | $31.05M | $-61.37M | $366.00M | $-172.00M | $-30.19M | $-410.19M | $-353.73M | $-475.08M | $-382.00M |
| Operating margin | -438.9% | -56.4% | -12.2% | -22.6% | -44.6% | -71.8% | -67.5% | -35.1% | -22.3% | -26.7% | -13.4% | 6.0% | -10.2% | 32.6% | -23.6% | -3.7% | -69.8% | -44.9% | -67.4% | -40.5% |
| EBITDA | $-58.54M | $-26.15M | $4.11M | $-16.21M | $-38.75M | $-56.27M | $-42.68M | $-41.88M | $-22.78M | $-40.94M | $-37.28M | $36.34M | $-18.84M | $381.99M | $-154.84M | $-5.19M | $-227.76M | $-235.87M | $-353.72M | $-286.75M |
| EBITDA margin | -394.0% | -44.8% | 3.8% | -13.3% | -35.7% | -56.8% | -41.8% | -28.4% | -10.6% | -14.4% | -10.8% | 7.1% | -3.1% | 34.0% | -21.2% | -0.6% | -38.8% | -29.9% | -50.2% | -30.4% |
| EBIT | $-65.75M | $-32.92M | $-2.71M | $-27.54M | $-47.93M | $-68.06M | $-53.44M | $-51.67M | $-32.18M | $-51.17M | $-46.32M | $27.99M | $-31.37M | $366.00M | $-172.00M | $-24.75M | $-249.86M | $-258.37M | $-375.71M | $-307.00M |
| Interest expense | $9.03M | $7.57M | $5.60M | $12.67M | $13.23M | $16.73M | $21.15M | $19.36M | $22.21M | $36.73M | $38.80M | $44.75M | $44.79M | $49.00M | $44.99M | $9.35M | $8.12M | $81.46M | $90.45M | $73.00M |
| Income tax | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Effective tax rate | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Net income | $-45.90M | $-10.99M | $-18.17M | $155.07M | $-61.25M | $-84.80M | $-65.48M | $-60.64M | $-38.98M | $-88.28M | $-86.56M | $346000.00 | $273.74M | $294.00M | $-487.00M | $-28.60M | $-269.72M | $-366.29M | $-453.90M | $-381.00M |
| Net income growth (YoY) | — | +76.0% | -65.3% | +953.3% | -139.5% | -38.4% | +22.8% | +7.4% | +35.7% | -126.4% | +2.0% | +100.4% | +79015.9% | +7.4% | -265.6% | +94.1% | -843.2% | -35.8% | -23.9% | +16.1% |
| Profit margin | -308.9% | -18.8% | -17.0% | 127.5% | -56.5% | -85.6% | -64.2% | -41.2% | -18.2% | -31.1% | -25.0% | 0.1% | 45.6% | 26.2% | -66.8% | -3.5% | -45.9% | -46.5% | -64.4% | -40.4% |