IONS
Ionis Pharmaceuticals Inc
NASDAQ: IONS · HEALTHCARE · BIOTECHNOLOGY
$74.76
-0.09% today
Updated 2026-04-30
Market cap
$11.85B
P/E ratio
—
P/S ratio
12.56x
EPS (TTM)
$-2.38
Dividend yield
—
52W range
$30 – $87
Volume
2.2M
Ionis Pharmaceuticals Inc (IONS) Earnings
Quarterly earnings history, analyst estimates, and stock price reaction.
EPS beat streak
8 of 8
Last 8 quarters
Avg EPS surprise
+64.1%
Last 4 quarters
Revenue YoY growth
-10.4%
Most recent quarter
EPS YoY growth
-166.8%
Most recent quarter
Earnings surprise history (last 12 quarters)
Beat estimate Missed estimate
Quarterly EPS and revenue trend
Quarterly revenue EPS (diluted)
How the stock reacts to earnings
Avg 1-day reaction
-0.4%
Last 3 reports
Positive reaction rate
67%
2 of 3 quarters
Largest single-day move
-5.7%
2026-02-25
| Report date | EPS actual | Surprise | Close before | Close after | 1-day reaction |
|---|---|---|---|---|---|
| 2026-02-25 | $-1.15 | +13.7% | $85.45 | $80.60 | -5.7% |
| 2025-10-29 | $-0.80 | +34.4% | $73.57 | $74.17 | +0.8% |
| 2025-07-30 | $0.70 | +391.7% | $41.48 | $42.98 | +3.6% |
Quarterly earnings history
| Fiscal quarter ending | EPS estimate | EPS actual | Surprise | Revenue | YoY revenue |
|---|---|---|---|---|---|
| 2025-12-31 | $-1.33 | $-1.15 | +13.7% | $203.00M | -10.4% |
| 2025-09-30 | $-1.22 | $-0.80 | +34.4% | $156.72M | +17.1% |
| 2025-06-30 | $-0.24 | $0.70 | +391.7% | $452.05M | +100.7% |
| 2025-03-31 | $-1.01 | $-0.92 | +8.5% | $131.61M | +10.1% |
| 2024-12-31 | $-0.84 | $-0.43 | +49.0% | $226.58M | +89.6% |
| 2024-09-30 | $-1.16 | $-0.95 | +18.1% | $133.81M | -7.2% |
| 2024-06-30 | $-0.92 | $-0.45 | +51.1% | $225.25M | +19.6% |
| 2024-03-31 | $-1.05 | $-0.98 | +6.7% | $119.50M | — |
| 2023-12-31 | $-0.83 | $-0.06 | +92.8% | $119.50M | — |
| 2023-09-30 | $-1.04 | $-1.03 | +1.0% | $144.21M | — |
| 2023-06-30 | $-0.90 | $-0.60 | +33.3% | $188.41M | — |
Frequently asked questions
Has Ionis Pharmaceuticals Inc beaten earnings estimates?
Ionis Pharmaceuticals Inc has beaten Wall Street EPS estimates in 8 of its last 8 quarterly reports, with an average EPS surprise of +64.1% over the last 4 quarters.
How does IONS stock react to earnings?
IONS stock has moved an average of -0.4% in the trading day following earnings over its last 3 reports, with positive reactions in 67% of those quarters.
What is Ionis Pharmaceuticals Inc's revenue growth rate?
Ionis Pharmaceuticals Inc reported year-over-year revenue growth of -10.4% in its most recent quarter, with EPS growing -166.8% year-over-year.