IONS
Ionis Pharmaceuticals Inc
NASDAQ: IONS · HEALTHCARE · BIOTECHNOLOGY
$75.38
-0.87% today
Updated 2026-06-05
Market cap
$12.11B
P/E ratio
—
P/S ratio
11.44x
EPS (TTM)
$-2.01
Dividend yield
—
52W range
$35 – $87
Volume
1.8M
Ionis Pharmaceuticals Inc (IONS) Insider transactions
Net insider activity
Net selling (704,162 shares)
Buy transactions
27
Sell transactions
73
All transactions
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-06-01 | BERTHELSEN, SPENCER R | Director | Sale | 8,000 | — | — |
| 2026-06-01 | BERTHELSEN, SPENCER R | Director | Sale | 8,000 | $75.67 | $605360.00 |
| 2026-05-14 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 3,220 | — | — |
| 2026-05-14 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 3,220 | $78.68 | $253347.35 |
| 2026-05-13 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 1,316 | — | — |
| 2026-05-13 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 1,316 | $78.01 | $102665.11 |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 16,000 | — | — |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 12,000 | — | — |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 10,968 | — | — |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 10,321 | — | — |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 59,508 | $74.90 | $4.46M |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 17,781 | $75.58 | $1.34M |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Buy | 16,000 | $64.80 | $1.04M |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Buy | 12,000 | $60.20 | $722400.00 |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Buy | 10,968 | $38.06 | $417442.08 |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Buy | 10,321 | $41.08 | $423986.68 |
| 2026-05-01 | KLEIN, JOSEPH III | Director | Sale | 10,111 | — | — |
| 2026-05-01 | KLEIN, JOSEPH III | Director | Buy | 10,111 | $47.11 | $476329.21 |
| 2026-05-01 | KLEIN, JOSEPH III | Director | Sale | 8,680 | $73.35 | $636704.04 |
| 2026-05-01 | KLEIN, JOSEPH III | Director | Sale | 1,431 | $74.45 | $106534.23 |
| 2026-04-28 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 1,626 | $71.79 | $116726.80 |
| 2026-04-16 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Sale | 4,902 | $75.17 | $368488.24 |
| 2026-04-16 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Sale | 973 | $75.04 | $73015.87 |
| 2026-04-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 5,619 | $74.56 | $418952.64 |
| 2026-04-15 | PARSHALL, B LYNNE | Director | Sale | 4,466 | $76.19 | $340264.54 |
| 2026-04-15 | PARSHALL, B LYNNE | Director | Sale | 534 | $76.97 | $41101.98 |
| 2026-04-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Sale | 12,226 | — | — |
| 2026-04-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Buy | 12,226 | — | — |
| 2026-04-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Sale | 1,875 | — | — |
| 2026-04-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Buy | 1,875 | — | — |
| 2026-04-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 10,837 | — | — |
| 2026-04-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Buy | 10,837 | — | — |
| 2026-04-02 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Sale | 6,193 | $74.05 | $458613.33 |
| 2026-04-01 | KLEIN, JOSEPH III | Director | Sale | 12,000 | — | — |
| 2026-04-01 | KLEIN, JOSEPH III | Director | Sale | 10,321 | — | — |
| 2026-04-01 | KLEIN, JOSEPH III | Director | Sale | 20,105 | $75.50 | $1.52M |
| 2026-04-01 | KLEIN, JOSEPH III | Director | Buy | 12,000 | $38.06 | $456720.00 |
| 2026-04-01 | KLEIN, JOSEPH III | Director | Buy | 10,321 | $41.08 | $423986.68 |
| 2026-04-01 | KLEIN, JOSEPH III | Director | Sale | 2,216 | $75.95 | $168314.06 |
| 2026-03-19 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Sale | 5,812 | $70.97 | $412486.36 |
| 2026-03-17 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Sale | 10,172 | $73.21 | $744661.60 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Sale | 61,041 | — | — |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Sale | 60,299 | — | — |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Sale | 33,118 | — | — |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Sale | 20,541 | — | — |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Sale | 205,608 | $72.38 | $14.88M |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Buy | 61,041 | $56.78 | $3.47M |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Buy | 60,299 | $60.89 | $3.67M |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Buy | 33,118 | $32.60 | $1.08M |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Buy | 20,541 | $37.58 | $771930.78 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Sale | 9,440 | $72.77 | $686901.60 |
| 2026-03-10 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 34,103 | — | — |
| 2026-03-10 | MONIA, BRETT P | Director, Chief Executive Officer | Buy | 34,103 | $60.89 | $2.08M |
| 2026-03-10 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 17,591 | $76.34 | $1.34M |
| 2026-03-10 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 16,512 | $75.47 | $1.25M |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Sale | 32,602 | — | — |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Sale | 4,675 | — | — |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Buy | 32,602 | $46.10 | $1.50M |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Sale | 21,191 | $75.50 | $1.60M |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Sale | 16,086 | $76.30 | $1.23M |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Buy | 4,675 | $34.69 | $162175.75 |
| 2026-03-09 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Sale | 10,148 | $75.25 | $763662.37 |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 73,529 | — | — |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 40,822 | — | — |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 117,604 | $75.26 | $8.85M |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | Buy | 73,529 | $60.89 | $4.48M |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | Buy | 40,822 | $60.89 | $2.49M |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 7,382 | $74.11 | $547087.40 |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 1,684 | $75.58 | $127281.77 |
| 2026-03-04 | LOSCALZO, JOSEPH | Director | Sale | 200 | — | — |
| 2026-03-04 | LOSCALZO, JOSEPH | Director | Buy | 200 | $38.06 | $7612.00 |
| 2026-03-04 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 238 | — | — |
| 2026-03-04 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 201 | — | — |
| 2026-03-04 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 238 | $80.00 | $19040.00 |
| 2026-03-04 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Buy | 201 | $32.60 | $6552.60 |
| 2026-03-03 | LOSCALZO, JOSEPH | Director | Sale | 832 | — | — |
| 2026-03-03 | LOSCALZO, JOSEPH | Director | Sale | 832 | $80.33 | $66832.81 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | Sale | 12,000 | — | — |
| 2026-03-03 | KLEIN, JOSEPH III | Director | Sale | 4,000 | — | — |
| 2026-03-03 | KLEIN, JOSEPH III | Director | Sale | 13,526 | $79.17 | $1.07M |
| 2026-03-03 | KLEIN, JOSEPH III | Director | Buy | 12,000 | $40.05 | $480600.00 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | Sale | 6,794 | $80.00 | $543486.03 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | Buy | 4,000 | $42.88 | $171520.00 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | Sale | 1,012 | $80.82 | $81787.82 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | Sale | 18,000 | — | — |
| 2026-03-03 | DIAZ, ALLENE M. | Director | Sale | 12,000 | — | — |
| 2026-03-03 | DIAZ, ALLENE M. | Director | Sale | 10,321 | — | — |
| 2026-03-03 | DIAZ, ALLENE M. | Director | Sale | 39,265 | $79.11 | $3.11M |
| 2026-03-03 | DIAZ, ALLENE M. | Director | Buy | 18,000 | $40.05 | $720900.00 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | Sale | 14,608 | $79.88 | $1.17M |
| 2026-03-03 | DIAZ, ALLENE M. | Director | Buy | 12,000 | $38.06 | $456720.00 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | Buy | 10,321 | $41.08 | $423986.68 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | Sale | 1,005 | $80.80 | $81203.00 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Sale | 6,951 | — | — |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Sale | 5,500 | — | — |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Sale | 3,760 | — | — |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Sale | 3,510 | — | — |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Sale | 385 | — | — |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Sale | 14,321 | $79.12 | $1.13M |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Buy | 6,951 | $32.60 | $226602.60 |
Frequently asked questions
Are IONS insiders buying or selling?
Over the transactions on record, IONS insiders have been net sellers, with about $50.71M in stock sold across 73 sales, against 24 open-market purchases.
Does insider selling at IONS mean the stock will fall?
Not by itself. Most executive selling is pre-scheduled through 10b5-1 plans filed months in advance, and insiders sell for diversification, taxes, and liquidity far more often than out of any view on the price. Insider buying is the stronger signal, especially when several insiders buy around the same time, because there is usually only one reason to put personal cash into the stock.
Which IONS insiders are selling the most?
Recent selling is concentrated in a few names. HOUGEN, ELIZABETH L accounts for the largest share on record, with about $16.31M sold. Selling by one or two individuals matters less than broad selling across the whole leadership team, which is the pattern worth watching.