IONS
Ionis Pharmaceuticals Inc
NASDAQ: IONS · HEALTHCARE · BIOTECHNOLOGY
$54.21
-2.59% today
Updated 2026-09-11
Market cap
$9.65B
P/E ratio
—
P/S ratio
11.04x
EPS (TTM)
$-3.48
Dividend yield
—
52W range
$50 – $87
Volume
3.4M
Ionis Pharmaceuticals Inc (IONS) Insider transactions
Net insider activity
Net selling (312,495 shares)
Buy transactions
45
Sell transactions
55
All transactions
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-08-31 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Buy | 63 | $51.31 | $3232.28 |
| 2026-08-31 | MONIA, BRETT P | Director, Chief Executive Officer | Buy | 98 | $51.31 | $5027.99 |
| 2026-08-31 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Buy | 58 | $51.31 | $2975.75 |
| 2026-08-31 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Buy | 110 | $51.31 | $5643.66 |
| 2026-07-31 | HAYDEN, MICHAEL R | Director | Buy | 5,000 | $51.60 | $258000.00 |
| 2026-07-30 | HAYDEN, MICHAEL R | Director | Buy | 15,000 | $53.38 | $800700.00 |
| 2026-07-15 | REIKES, PETER N | Director | Buy | 3,399 | — | — |
| 2026-07-15 | HERMAN, JOAN E | Director | Sale | 5,220 | — | — |
| 2026-07-15 | HERMAN, JOAN E | Director | Buy | 5,220 | — | — |
| 2026-07-15 | HANTSON, LUDWIG | Director | Buy | 3,399 | — | — |
| 2026-07-15 | BERTHELSEN, SPENCER R | Director | Sale | 5,220 | — | — |
| 2026-07-15 | BERTHELSEN, SPENCER R | Director | Buy | 5,220 | — | — |
| 2026-07-07 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Sale | 362 | $84.30 | $30516.60 |
| 2026-07-07 | DIAZ, ALLENE M. | Director | Sale | 10,111 | — | — |
| 2026-07-07 | DIAZ, ALLENE M. | Director | Buy | 10,111 | $47.11 | $476329.21 |
| 2026-07-07 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Sale | 15,000 | — | — |
| 2026-07-07 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Buy | 15,000 | — | — |
| 2026-07-07 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Sale | 5,536 | $83.58 | $462693.34 |
| 2026-07-01 | YANG, MICHAEL J. | Director | Buy | 2,301 | — | — |
| 2026-07-01 | YANG, MICHAEL J. | Director | Buy | 5,369 | — | — |
| 2026-07-01 | LOSCALZO, JOSEPH | Director | Buy | 2,301 | — | — |
| 2026-07-01 | LOSCALZO, JOSEPH | Director | Buy | 5,369 | — | — |
| 2026-07-01 | KLEIN, JOSEPH III | Director | Buy | 2,301 | — | — |
| 2026-07-01 | KLEIN, JOSEPH III | Director | Sale | 11,518 | — | — |
| 2026-07-01 | KLEIN, JOSEPH III | Director | Buy | 5,369 | — | — |
| 2026-07-01 | KLEIN, JOSEPH III | Director | Buy | 11,518 | $39.94 | $460028.92 |
| 2026-07-01 | KLEIN, JOSEPH III | Director | Sale | 11,419 | $79.04 | $902550.91 |
| 2026-07-01 | KLEIN, JOSEPH III | Director | Sale | 99 | $79.45 | $7865.55 |
| 2026-07-01 | HERMAN, JOAN E | Director | Buy | 2,301 | — | — |
| 2026-07-01 | HERMAN, JOAN E | Director | Buy | 5,369 | — | — |
| 2026-07-01 | HAYDEN, MICHAEL R | Director | Buy | 2,301 | — | — |
| 2026-07-01 | HAYDEN, MICHAEL R | Director | Buy | 5,369 | — | — |
| 2026-07-01 | DIAZ, ALLENE M. | Director | Buy | 2,301 | — | — |
| 2026-07-01 | DIAZ, ALLENE M. | Director | Buy | 5,369 | — | — |
| 2026-07-01 | BERTHELSEN, SPENCER R | Director | Buy | 2,301 | — | — |
| 2026-07-01 | BERTHELSEN, SPENCER R | Director | Buy | 5,369 | — | — |
| 2026-06-26 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Sale | 26,000 | — | — |
| 2026-06-26 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Buy | 26,000 | $60.89 | $1.58M |
| 2026-06-26 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Sale | 3,069 | $80.00 | $245520.00 |
| 2026-06-26 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 50,000 | — | — |
| 2026-06-26 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 50,000 | $80.59 | $4.03M |
| 2026-06-26 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 3,866 | — | — |
| 2026-06-26 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 1,769 | — | — |
| 2026-06-26 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 5,635 | $80.16 | $451698.78 |
| 2026-06-26 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Buy | 3,866 | $56.78 | $219511.48 |
| 2026-06-26 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Buy | 1,769 | $32.60 | $57669.40 |
| 2026-06-25 | SWAYZE, ERIC | EVP Research | Sale | 10,602 | $79.18 | $839491.80 |
| 2026-06-25 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 21,072 | — | — |
| 2026-06-25 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 21,072 | $78.49 | $1.65M |
| 2026-06-24 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 14,565 | — | — |
| 2026-06-24 | MONIA, BRETT P | Director, Chief Executive Officer | Buy | 14,565 | $32.60 | $474819.00 |
| 2026-06-15 | BERTHELSEN, SPENCER R | Director | Sale | 8,000 | — | — |
| 2026-06-15 | BERTHELSEN, SPENCER R | Director | Sale | 8,000 | $73.49 | $587920.00 |
| 2026-06-12 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Sale | 21,000 | — | — |
| 2026-06-12 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Sale | 19,895 | — | — |
| 2026-06-12 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Sale | 12,000 | — | — |
| 2026-06-12 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Sale | 7,951 | — | — |
| 2026-06-12 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Sale | 41,004 | $73.09 | $3.00M |
| 2026-06-12 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Buy | 21,000 | $60.89 | $1.28M |
| 2026-06-12 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Buy | 19,895 | $56.78 | $1.13M |
| 2026-06-12 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Sale | 19,842 | $74.05 | $1.47M |
| 2026-06-12 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Buy | 12,000 | $32.60 | $391200.00 |
| 2026-06-12 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Buy | 7,951 | $60.89 | $484136.39 |
| 2026-06-04 | REIKES, PETER N | Director | Buy | 10,753 | — | — |
| 2026-06-04 | HANTSON, LUDWIG | Director | Buy | 10,753 | — | — |
| 2026-06-01 | BERTHELSEN, SPENCER R | Director | Sale | 8,000 | — | — |
| 2026-06-01 | BERTHELSEN, SPENCER R | Director | Sale | 8,000 | $75.67 | $605360.00 |
| 2026-05-14 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 3,220 | — | — |
| 2026-05-14 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 3,220 | $78.68 | $253347.35 |
| 2026-05-13 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 1,316 | — | — |
| 2026-05-13 | MONIA, BRETT P | Director, Chief Executive Officer | Sale | 1,316 | $78.01 | $102665.11 |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 16,000 | — | — |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 12,000 | — | — |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 10,968 | — | — |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 10,321 | — | — |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 59,508 | $74.90 | $4.46M |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Sale | 17,781 | $75.58 | $1.34M |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Buy | 16,000 | $64.80 | $1.04M |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Buy | 12,000 | $60.20 | $722400.00 |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Buy | 10,968 | $38.06 | $417442.08 |
| 2026-05-04 | LOSCALZO, JOSEPH | Director | Buy | 10,321 | $41.08 | $423986.68 |
| 2026-05-01 | KLEIN, JOSEPH III | Director | Sale | 10,111 | — | — |
| 2026-05-01 | KLEIN, JOSEPH III | Director | Buy | 10,111 | $47.11 | $476329.21 |
| 2026-05-01 | KLEIN, JOSEPH III | Director | Sale | 8,680 | $73.35 | $636704.04 |
| 2026-05-01 | KLEIN, JOSEPH III | Director | Sale | 1,431 | $74.45 | $106534.23 |
| 2026-04-28 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 1,626 | $71.79 | $116726.80 |
| 2026-04-16 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Sale | 4,902 | $75.17 | $368488.24 |
| 2026-04-16 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Sale | 973 | $75.04 | $73015.87 |
| 2026-04-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 5,619 | $74.56 | $418952.64 |
| 2026-04-15 | PARSHALL, B LYNNE | Director | Sale | 4,466 | $76.19 | $340264.54 |
| 2026-04-15 | PARSHALL, B LYNNE | Director | Sale | 534 | $76.97 | $41101.98 |
| 2026-04-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Sale | 12,226 | — | — |
| 2026-04-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Buy | 12,226 | — | — |
| 2026-04-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Sale | 1,875 | — | — |
| 2026-04-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Buy | 1,875 | — | — |
| 2026-04-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Sale | 10,837 | — | — |
| 2026-04-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Buy | 10,837 | — | — |
| 2026-04-02 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Sale | 6,193 | $74.05 | $458613.33 |
| 2026-04-01 | KLEIN, JOSEPH III | Director | Sale | 12,000 | — | — |
| 2026-04-01 | KLEIN, JOSEPH III | Director | Sale | 10,321 | — | — |
Frequently asked questions
Are IONS insiders buying or selling?
Over the transactions on record, IONS insiders have been net sellers, with about $23.00M in stock sold across 55 sales, against 21 open-market purchases.
Does insider selling at IONS mean the stock will fall?
Not by itself. Most executive selling is pre-scheduled through 10b5-1 plans filed months in advance, and insiders sell for diversification, taxes, and liquidity far more often than out of any view on the price. Insider buying is the stronger signal, especially when several insiders buy around the same time, because there is usually only one reason to put personal cash into the stock.
Which IONS insiders are selling the most?
Recent selling is concentrated in a few names. MONIA, BRETT P accounts for the largest share on record, with about $6.04M sold. Selling by one or two individuals matters less than broad selling across the whole leadership team, which is the pattern worth watching.