What is Upstream Bio, Inc. (UPB) stock price today?

Upstream Bio, Inc. (UPB) currently trades at $9.19 per share. The stock has a market capitalization of $500.12M and a P/E ratio of —x.

Is UPB stock a buy, sell, or hold in 2026?

Based on WallStSmart's proprietary analysis, Upstream Bio, Inc. has a Smart Value Score of 32/100 (Grade F), resulting in a "Strong Sell" investment rating. The Piotroski F-Score is —/9 and Altman Z-Score is —.

What is Upstream Bio, Inc.'s revenue and earnings?

Upstream Bio, Inc. has trailing twelve-month (TTM) revenue of $2.85M with profit margins of 0.00%. Earnings per share (EPS) is $-2.66.

UPB

Upstream Bio, Inc.

NASDAQ: UPB · HEALTHCARE · BIOTECHNOLOGY

$9.19

-3.36% today

Updated 2026-04-29

Market cap

$500.12M

P/E ratio

—

P/S ratio

175.23x

EPS (TTM)

$-2.66

Dividend yield

—

52W range

$7 – $34

Volume

1.0M

Market cap

$500.12M

P/E ratio

—

P/S ratio

175.23x

EPS (TTM)

$-2.66

Dividend yield

—

52W range

$7 – $34

Volume

1.0M

WallStSmart proprietary scores

out of 100

Grade: F

Strong Sell

Investment rating

6.7

Growth

5.0

Quality

C+

2.5

Profitability

5.0

Valuation

C+

—/9

Piotroski F-Score

—

Altman Z-Score

—

Industry rank

—

View all highly rated stocks (75+) →201 stocks currently score above 75

Price targets

Analyst target

$43.57

+374.10%

12-Month target

—

Intrinsic (DCF)

—

Margin of safety

—

2 Strong Buy5 Buy1 Hold0 Sell0 Strong Sell

Price chart

X-Ray snapshot

Strengths

Insufficient data

Risks

- Thin margins at 0.00%

- Negative free cash flow $-30.68M

Key financials

Revenue Net Income Free Cash Flow

Metric	2022	2023	2024	2025	TTM
Revenue	$1.21M	$2.38M	$2.37M	$2.85M	$2.85M
Net income	$-23.87M	$-20.54M	$-62.81M	$-143.44M	$-42.46M
EPS	—	—	—	—	$-2.66
Free cash flow	$-19.10M	$-38.07M	$-59.68M	$-133.44M	$-30.68M
Profit margin	-1,969.31%	-862.90%	-2,650.04%	-5,026.03%	—

Peer comparison

Company	Mkt Cap	Score	Growth	Profit	Value	Quality	MoS	Rating
UPB	$500.12M	32	6.7	2.5	5.0	5.0	—	Avoid
LLY	$760.43B	78	10.0	10.0	5.0	6.5	—	Strong Buy
JNJ	$547.28B	59	4.7	9.0	3.3	6.0	-43.54%	Buy
ABBV	$360.63B	63	4.0	8.0	4.7	5.0	-29.31%	Buy
UNH	$322.34B	54	5.3	5.5	7.3	4.8	+42.06%	Buy
AZN	$294.17B	64	6.7	8.0	5.3	5.0	+4.07%	Buy

Smart narrative

Upstream Bio, Inc. trades at $9.19. Our Smart Value Score of 32/100 indicates the stock is weak. TTM revenue stands at $2.85M.

Frequently asked questions

What is Upstream Bio, Inc.'s stock price?

Upstream Bio, Inc. (UPB) trades at $9.19.

Is Upstream Bio, Inc. overvalued?

Smart Value Score 32/100 (Grade F, Strong Sell).

What is the price target of Upstream Bio, Inc. (UPB)?

The analyst target price is $43.57, representing +374.1% upside from the current price of $9.19.

What is Upstream Bio, Inc.'s revenue?

TTM revenue is $2.85M.

Company info

SectorHEALTHCARE

IndustryBIOTECHNOLOGY

CountryUSA

ExchangeNASDAQ

CurrencyUSD

Quick metrics

P/S ratio175.23x

ROE-35.40%

Beta—

50D MA$8.99

200D MA$18.89

Shares out0.05B

Float0.03B

Short ratio—

Avg volume1.0M

Performance

1 week+0.32%

1 month+7.15%

3 months-71.42%

YTD-65.78%

1 year—

3 years—

5 years—

Compare

UPB vs LLY →UPB vs JNJ →UPB vs ABBV →Stock screener →