UPB
Upstream Bio, Inc.
NASDAQ: UPB · HEALTHCARE · BIOTECHNOLOGY
$9.19
-3.36% today
Updated 2026-04-29
Market cap
$500.12M
P/E ratio
—
P/S ratio
175.23x
EPS (TTM)
$-2.66
Dividend yield
—
52W range
$7 – $34
Volume
1.0M
Upstream Bio, Inc. (UPB) Earnings
Quarterly earnings history, analyst estimates, and stock price reaction.
EPS beat streak
2 of 7
Last 7 quarters
Avg EPS surprise
-5.2%
Last 4 quarters
Revenue YoY growth
+9.0%
Most recent quarter
EPS YoY growth
-90.2%
Most recent quarter
Earnings surprise history (last 12 quarters)
Beat estimate Missed estimate
Quarterly EPS and revenue trend
Quarterly revenue EPS (diluted)
How the stock reacts to earnings
Avg 1-day reaction
+2.9%
Last 3 reports
Positive reaction rate
67%
2 of 3 quarters
Largest single-day move
+12.1%
2026-03-24
| Report date | EPS actual | Surprise | Close before | Close after | 1-day reaction |
|---|---|---|---|---|---|
| 2026-03-24 | $-0.78 | -11.4% | $8.45 | $9.47 | +12.1% |
| 2025-11-05 | $-0.63 | +18.2% | $25.04 | $23.66 | -5.5% |
| 2025-08-06 | $-0.74 | -21.3% | $15.50 | $15.84 | +2.2% |
Quarterly earnings history
| Fiscal quarter ending | EPS estimate | EPS actual | Surprise | Revenue | YoY revenue |
|---|---|---|---|---|---|
| 2025-12-31 | $-0.70 | $-0.78 | -11.4% | $668000.00 | +9.0% |
| 2025-09-30 | $-0.77 | $-0.63 | +18.2% | $683000.00 | +12.5% |
| 2025-06-30 | $-0.61 | $-0.74 | -21.3% | $937000.00 | +83.7% |
| 2025-03-31 | $-0.48 | $-0.51 | -6.3% | $566000.00 | — |
| 2024-12-31 | $-0.54 | $-0.41 | +24.1% | $613000.00 | — |
| 2024-09-30 | $-3.65 | $-6.96 | -90.7% | $607000.00 | — |
| 2024-06-30 | $0.00 | $-11.18 | — | $510000.00 | — |
Frequently asked questions
Has Upstream Bio, Inc. beaten earnings estimates?
Upstream Bio, Inc. has beaten Wall Street EPS estimates in 2 of its last 7 quarterly reports, with an average EPS surprise of -5.2% over the last 4 quarters.
How does UPB stock react to earnings?
UPB stock has moved an average of +2.9% in the trading day following earnings over its last 3 reports, with positive reactions in 67% of those quarters.
What is Upstream Bio, Inc.'s revenue growth rate?
Upstream Bio, Inc. reported year-over-year revenue growth of +9.0% in its most recent quarter, with EPS growing -90.2% year-over-year.