SPRO
Spero Therapeutics Inc
NASDAQ: SPRO · HEALTHCARE · BIOTECHNOLOGY
$2.51
-0.79% today
Updated 2026-04-30
Market cap
$154.60M
P/E ratio
17.80
P/S ratio
2.31x
EPS (TTM)
$0.15
Dividend yield
—
52W range
$1 – $3
Volume
0.4M
Spero Therapeutics Inc (SPRO) Earnings
Quarterly earnings history, analyst estimates, and stock price reaction.
EPS beat streak
5 of 8
Last 8 quarters
Avg EPS surprise
+72.2%
Last 4 quarters
Revenue YoY growth
+163.6%
Most recent quarter
EPS YoY growth
+244.7%
Most recent quarter
Earnings surprise history (last 12 quarters)
Beat estimate Missed estimate
Quarterly EPS and revenue trend
Quarterly revenue EPS (diluted)
How the stock reacts to earnings
Avg 1-day reaction
-1.5%
Last 2 reports
Positive reaction rate
50%
1 of 2 quarters
Largest single-day move
-5.5%
2026-03-27
| Report date | EPS actual | Surprise | Close before | Close after | 1-day reaction |
|---|---|---|---|---|---|
| 2026-03-27 | $0.53 | — | $2.37 | $2.24 | -5.5% |
| 2025-11-17 | $-0.13 | +66.7% | $2.41 | $2.47 | +2.5% |
Quarterly earnings history
| Fiscal quarter ending | EPS estimate | EPS actual | Surprise | Revenue | YoY revenue |
|---|---|---|---|---|---|
| 2025-12-31 | — | $0.53 | — | $39.66M | +163.6% |
| 2025-09-30 | $-0.39 | $-0.13 | +66.7% | $3.05M | -77.4% |
| 2025-06-30 | $-0.57 | $-0.03 | +94.7% | $11.80M | +15.7% |
| 2025-03-31 | $-0.55 | $-0.25 | +55.1% | $5.87M | +39.7% |
| 2024-12-31 | $-0.31 | $-0.37 | -18.4% | $15.04M | -79.5% |
| 2024-09-30 | $-0.50 | $-0.32 | +36.0% | $13.47M | -47.1% |
| 2024-06-30 | $-0.38 | $-0.33 | +13.2% | $10.20M | +275.4% |
| 2024-03-31 | $-0.04 | $-0.24 | -500.0% | $4.20M | +103.2% |
| 2023-12-31 | $-0.10 | $0.96 | +1060.0% | $73.52M | — |
| 2023-09-30 | $-0.03 | $0.04 | +233.3% | $25.47M | — |
| 2023-06-30 | $-0.34 | $-0.23 | +32.4% | $2.72M | — |
| 2023-03-31 | $-0.33 | $-0.25 | +24.2% | $2.07M | — |
Frequently asked questions
Has Spero Therapeutics Inc beaten earnings estimates?
Spero Therapeutics Inc has beaten Wall Street EPS estimates in 5 of its last 8 quarterly reports, with an average EPS surprise of +72.2% over the last 3 quarters.
How does SPRO stock react to earnings?
SPRO stock has moved an average of -1.5% in the trading day following earnings over its last 2 reports, with positive reactions in 50% of those quarters.
What is Spero Therapeutics Inc's revenue growth rate?
Spero Therapeutics Inc reported year-over-year revenue growth of +163.6% in its most recent quarter, with EPS growing +244.7% year-over-year.