What is Sionna Therapeutics, Inc. Common Stock (SION) stock price today?

Sionna Therapeutics, Inc. Common Stock (SION) currently trades at $45.95 per share. The stock has a market capitalization of $1.96B and a P/E ratio of —x.

Is SION stock a buy, sell, or hold in 2026?

Based on WallStSmart's proprietary analysis, Sionna Therapeutics, Inc. Common Stock has a Smart Value Score of 23/100 (Grade F), resulting in a "Strong Sell" investment rating. The Piotroski F-Score is 4/9 and Altman Z-Score is -2.04.

Is Sionna Therapeutics, Inc. Common Stock financially healthy?

Sionna Therapeutics, Inc. Common Stock's Piotroski F-Score is 4/9 (moderate financial health). The Altman Z-Score of -2.04 places it in the distress.

SION

Sionna Therapeutics, Inc. Common Stock

NASDAQ: SION · HEALTHCARE · BIOTECHNOLOGY

$45.95

+3.89% today

Updated 2026-05-11

Market cap

$1.96B

P/E ratio

—

P/S ratio

—

EPS (TTM)

$-1.88

Dividend yield

—

52W range

$12 – $46

Volume

0.4M

Market cap

$1.96B

P/E ratio

—

P/S ratio

—

EPS (TTM)

$-1.88

Dividend yield

—

52W range

$12 – $46

Volume

0.4M

WallStSmart proprietary scores

out of 100

Grade: F

Strong Sell

Investment rating

4.3

Growth

7.0

Quality

B+

3.0

Profitability

5.0

Valuation

C+

4/9

Piotroski F-Score

Moderate

-2.0

Altman Z-Score

Distress

—

Industry rank

—

View all highly rated stocks (75+) →198 stocks currently score above 75

Price targets

Analyst target

$50.60

+10.12%

12-Month target

—

Intrinsic (DCF)

—

Margin of safety

—

1 Strong Buy8 Buy0 Hold0 Sell1 Strong Sell

Price chart

Stock snapshot

Strengths

+ Debt/equity 0.03x — low leverage

Risks

- Altman Z -2.04 — distress zone

- Thin margins at 0.00%

- Negative free cash flow $-16.83M

Key financials

Revenue Net Income Free Cash Flow

Metric	2022	2023	2024	2025	TTM
Revenue	$0.00	$0.00	$0.00	$0.00	$0.00
Net income	$-40.24M	$-47.26M	$-61.69M	$-75.27M	$-20.44M
EPS	—	—	—	—	$-1.88
Free cash flow	$-37.94M	$-44.81M	$-52.81M	$-66.67M	$-16.83M
Profit margin	—	—	—	—	—

Peer comparison

Company	Mkt Cap	Score	Growth	Profit	Value	Quality	MoS	Rating
SION	$1.96B	23	4.3	3.0	5.0	7.0	—	Avoid
LLY	$869.41B	78	10.0	10.0	5.0	6.5	—	Strong Buy
JNJ	$535.63B	59	4.7	9.0	3.3	6.0	-37.47%	Buy
ABBV	$358.55B	63	4.0	8.0	4.0	5.0	-19.74%	Buy
UNH	$335.78B	54	5.3	5.5	7.3	4.8	+40.60%	Buy
AZN	$283.47B	62	6.0	8.5	5.3	5.0	+6.51%	Buy

Smart narrative

Sionna Therapeutics, Inc. Common Stock trades at $45.95. Our Smart Value Score of 23/100 indicates the stock is weak. The company scores 4/9 on the Piotroski F-Score. With an Altman Z-Score of -2.04, it sits in the distress.

Frequently asked questions

What is Sionna Therapeutics, Inc. Common Stock's stock price?

Sionna Therapeutics, Inc. Common Stock (SION) trades at $45.95.

Is Sionna Therapeutics, Inc. Common Stock overvalued?

Smart Value Score 23/100 (Grade F, Strong Sell).

What is the price target of Sionna Therapeutics, Inc. Common Stock (SION)?

The analyst target price is $50.60, representing +10.1% upside from the current price of $45.95.

Piotroski F-Score?

4/9 — moderate financial health.

Altman Z-Score?

-2.04 — distress.

Company info

SectorHEALTHCARE

IndustryBIOTECHNOLOGY

CountryUSA

ExchangeNASDAQ

CurrencyUSD

www.sionnatx.com

Quick metrics

P/S ratio—

ROE-31.80%

Beta—

50D MA$38.58

200D MA$34.54

Shares out0.05B

Float0.02B

Short ratio—

Avg volume0.4M

Performance

1 week—

1 month—

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YTD—

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Compare

SION vs LLY →SION vs JNJ →SION vs ABBV →Stock screener →