SEPN
Septerna, Inc. Common Stock
NASDAQ: SEPN · HEALTHCARE · BIOTECHNOLOGY
$23.76
+1.32% today
Updated 2026-04-30
Market cap
$1.05B
P/E ratio
—
P/S ratio
22.92x
EPS (TTM)
$-1.10
Dividend yield
—
52W range
$6 – $33
Volume
0.3M
Septerna, Inc. Common Stock (SEPN) Earnings
Quarterly earnings history, analyst estimates, and stock price reaction.
EPS beat streak
5 of 7
Last 7 quarters
Avg EPS surprise
+53.7%
Last 4 quarters
Revenue YoY growth
+11276.4%
Most recent quarter
EPS YoY growth
+62.5%
Most recent quarter
Earnings surprise history (last 12 quarters)
Beat estimate Missed estimate
Quarterly EPS and revenue trend
Quarterly revenue EPS (diluted)
How the stock reacts to earnings
Avg 1-day reaction
-0.6%
Last 3 reports
Positive reaction rate
33%
1 of 3 quarters
Largest single-day move
-4.2%
2025-08-11
| Report date | EPS actual | Surprise | Close before | Close after | 1-day reaction |
|---|---|---|---|---|---|
| 2026-03-26 | $-0.24 | +66.7% | $24.21 | $23.87 | -1.4% |
| 2025-11-10 | $0.18 | +127.7% | $18.51 | $19.24 | +3.9% |
| 2025-08-11 | $-0.56 | +11.1% | $11.69 | $11.20 | -4.2% |
Quarterly earnings history
| Fiscal quarter ending | EPS estimate | EPS actual | Surprise | Revenue | YoY revenue |
|---|---|---|---|---|---|
| 2025-12-31 | $-0.72 | $-0.24 | +66.7% | $24.12M | +11276.4% |
| 2025-09-30 | $-0.65 | $0.18 | +127.7% | $21.50M | +12113.1% |
| 2025-06-30 | $-0.63 | $-0.56 | +11.1% | $119000.00 | -67.8% |
| 2025-03-31 | $-0.54 | $-0.49 | +9.3% | $219000.00 | — |
| 2024-12-31 | $-0.69 | $-0.64 | +6.8% | $212000.00 | — |
| 2024-09-30 | — | $-4.62 | — | $176000.00 | — |
| 2024-06-30 | $0.00 | $-12.76 | — | $370000.00 | — |
Frequently asked questions
Has Septerna, Inc. Common Stock beaten earnings estimates?
Septerna, Inc. Common Stock has beaten Wall Street EPS estimates in 5 of its last 7 quarterly reports, with an average EPS surprise of +53.7% over the last 4 quarters.
How does SEPN stock react to earnings?
SEPN stock has moved an average of -0.6% in the trading day following earnings over its last 3 reports, with positive reactions in 33% of those quarters.
What is Septerna, Inc. Common Stock's revenue growth rate?
Septerna, Inc. Common Stock reported year-over-year revenue growth of +11276.4% in its most recent quarter, with EPS growing +62.5% year-over-year.