WallStSmart

TG Therapeutics Inc (TGTX)vsVertex Pharmaceuticals Inc (VRTX)

VS

Smart Verdict

WallStSmart Research — data-driven comparison

Vertex Pharmaceuticals Inc generates 1847% more annual revenue ($12.00B vs $616.29M). TGTX leads profitability with a 72.6% profit margin vs 32.9%. TGTX appears more attractively valued with a PEG of 1.61. VRTX earns a higher WallStSmart Score of 66/100 (B-).

TGTX

Buy

63

out of 100

Grade: C+

Growth: 5.7Profit: 9.5Value: 7.3Quality: 5.8
Piotroski: 4/9Altman Z: -0.51

VRTX

Strong Buy

66

out of 100

Grade: B-

Growth: 8.0Profit: 9.0Value: 10.0Quality: 8.0
Piotroski: 3/9Altman Z: 3.62
IV

Intrinsic Value Comparison

Multi-model valuation · Graham Formula

TGTXSignificantly Overvalued (-53.0%)

Margin of Safety

-53.0%

Fair Value

$18.84

Current Price

$31.82

$12.98 premium

UndervaluedFair: $18.84Overvalued
VRTXUndervalued (+36.5%)

Margin of Safety

+36.5%

Fair Value

$716.04

Current Price

$454.97

$261.07 discount

UndervaluedFair: $716.04Overvalued

Key Strengths & Concerns

Side-by-side fundamental analysis

Key Strengths

TGTX5 strengths · Avg: 9.6/10
P/E RatioValuation
10.9x10/10

Attractively priced relative to earnings

Return on EquityProfitability
102.8%10/10

Every $100 of equity generates 103 in profit

Profit MarginProfitability
72.6%10/10

Keeps 73 of every $100 in revenue as profit

Revenue GrowthGrowth
78.0%10/10

Revenue surging 78.0% year-over-year

Operating MarginProfitability
26.2%8/10

Strong operational efficiency at 26.2%

VRTX6 strengths · Avg: 9.5/10
Profit MarginProfitability
32.9%10/10

Keeps 33 of every $100 in revenue as profit

Operating MarginProfitability
39.6%10/10

Strong operational efficiency at 39.6%

Altman Z-ScoreHealth
3.6210/10

Safe zone — low bankruptcy risk

Market CapQuality
$113.95B9/10

Large-cap with strong market position

Return on EquityProfitability
22.5%9/10

Every $100 of equity generates 23 in profit

Debt/EquityHealth
0.219/10

Conservative balance sheet, low leverage

Areas to Watch

TGTX3 concerns · Avg: 2.7/10
PEG RatioValuation
1.614/10

Expensive relative to growth rate

EPS GrowthGrowth
-6.1%2/10

Earnings declined 6.1%

Altman Z-ScoreHealth
-0.512/10

Distress zone — elevated risk

VRTX3 concerns · Avg: 3.7/10
PEG RatioValuation
2.194/10

Expensive relative to growth rate

P/E RatioValuation
29.3x4/10

Moderate valuation

Piotroski F-ScoreQuality
3/93/10

Weak financial health signals

Comparative Analysis Report

WallStSmart Research

Bull Case : TGTX

The strongest argument for TGTX centers on P/E Ratio, Return on Equity, Profit Margin. Profitability is solid with margins at 72.6% and operating margin at 26.2%. Revenue growth of 78.0% demonstrates continued momentum.

Bull Case : VRTX

The strongest argument for VRTX centers on Profit Margin, Operating Margin, Altman Z-Score. Profitability is solid with margins at 32.9% and operating margin at 39.6%.

Bear Case : TGTX

The primary concerns for TGTX are PEG Ratio, EPS Growth, Altman Z-Score.

Bear Case : VRTX

The primary concerns for VRTX are PEG Ratio, P/E Ratio, Piotroski F-Score.

Key Dynamics to Monitor

TGTX profiles as a growth stock while VRTX is a mature play — different risk/reward profiles.

TGTX carries more volatility with a beta of 1.86 — expect wider price swings.

TGTX is growing revenue faster at 78.0% — sustainability is the question.

VRTX generates stronger free cash flow (349M), providing more financial flexibility.

Bottom Line

VRTX scores higher overall (66/100 vs 63/100), backed by strong 32.9% margins. Both earn "Strong Buy" and "Buy" ratings respectively — the choice depends on your investment horizon and risk tolerance.

This analysis is generated from publicly available financial data. Not financial advice.

TG Therapeutics Inc

HEALTHCARE · BIOTECHNOLOGY · USA

TG Therapeutics, Inc., a commercial-stage biopharmaceutical company, focuses on the acquisition, development, and commercialization of novel treatments for B-cell malignancies and autoimmune diseases. The company is headquartered in New York, New York.

Vertex Pharmaceuticals Inc

HEALTHCARE · BIOTECHNOLOGY · USA

Vertex Pharmaceuticals, Inc. is an American biopharmaceutical company based in Boston, Massachusetts.

Want to dig deeper into these stocks?