WallStSmart

Alnylam Pharmaceuticals Inc (ALNY)vsAscendis Pharma AS (ASND)

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Smart Verdict

WallStSmart Research — data-driven comparison

Alnylam Pharmaceuticals Inc generates 395% more annual revenue ($4.29B vs $865.78M). ASND leads profitability with a 57.3% profit margin vs 12.6%. ASND trades at a lower P/E of 24.7x. ALNY earns a higher WallStSmart Score of 65/100 (B-).

ALNY

Strong Buy

65

out of 100

Grade: B-

Growth: 8.0Profit: 8.0Value: 7.3Quality: 5.5
Piotroski: 4/9Altman Z: -0.07

ASND

Buy

55

out of 100

Grade: C

Growth: 8.0Profit: 7.0Value: 5.3Quality: 3.0
Piotroski: 3/9Altman Z: -2.67
IV

Intrinsic Value Comparison

Multi-model valuation · Graham Formula

ALNYUndervalued (+86.4%)

Margin of Safety

+86.4%

Fair Value

$2372.19

Current Price

$303.05

$2069.14 discount

UndervaluedFair: $2372.19Overvalued

Intrinsic value data unavailable for ASND.

Key Strengths & Concerns

Side-by-side fundamental analysis

Key Strengths

ALNY4 strengths · Avg: 9.5/10
PEG RatioValuation
0.4810/10

Growing faster than its price suggests

Return on EquityProfitability
53.7%10/10

Every $100 of equity generates 54 in profit

Revenue GrowthGrowth
96.4%10/10

Revenue surging 96.4% year-over-year

Operating MarginProfitability
23.0%8/10

Strong operational efficiency at 23.0%

ASND3 strengths · Avg: 10.0/10
Return on EquityProfitability
103.7%10/10

Every $100 of equity generates 104 in profit

Profit MarginProfitability
57.3%10/10

Keeps 57 of every $100 in revenue as profit

Revenue GrowthGrowth
144.3%10/10

Revenue surging 144.3% year-over-year

Areas to Watch

ALNY4 concerns · Avg: 2.8/10
EPS GrowthGrowth
0.0%4/10

0.0% earnings growth

Debt/EquityHealth
1.183/10

Elevated debt levels

P/E RatioValuation
70.9x2/10

Premium valuation, high expectations priced in

Price/BookValuation
37.6x2/10

Trading at 37.6x book value

ASND4 concerns · Avg: 3.0/10
EPS GrowthGrowth
0.0%4/10

0.0% earnings growth

Debt/EquityHealth
1.843/10

Elevated debt levels

Piotroski F-ScoreQuality
3/93/10

Weak financial health signals

Price/BookValuation
23.3x2/10

Trading at 23.3x book value

Comparative Analysis Report

WallStSmart Research

Bull Case : ALNY

The strongest argument for ALNY centers on PEG Ratio, Return on Equity, Revenue Growth. Revenue growth of 96.4% demonstrates continued momentum. PEG of 0.48 suggests the stock is reasonably priced for its growth.

Bull Case : ASND

The strongest argument for ASND centers on Return on Equity, Profit Margin, Revenue Growth. Profitability is solid with margins at 57.3% and operating margin at 10.1%. Revenue growth of 144.3% demonstrates continued momentum.

Bear Case : ALNY

The primary concerns for ALNY are EPS Growth, Debt/Equity, P/E Ratio. A P/E of 70.9x leaves little room for execution misses.

Bear Case : ASND

The primary concerns for ASND are EPS Growth, Debt/Equity, Piotroski F-Score. Debt-to-equity of 1.84 is elevated, increasing financial risk.

Key Dynamics to Monitor

ASND carries more volatility with a beta of 0.48 — expect wider price swings.

ASND is growing revenue faster at 144.3% — sustainability is the question.

ALNY generates stronger free cash flow (49M), providing more financial flexibility.

Monitor BIOTECHNOLOGY industry trends, competitive dynamics, and regulatory changes.

Bottom Line

ALNY scores higher overall (65/100 vs 55/100) and 96.4% revenue growth. Both earn "Strong Buy" and "Buy" ratings respectively — the choice depends on your investment horizon and risk tolerance.

This analysis is generated from publicly available financial data. Not financial advice.

Alnylam Pharmaceuticals Inc

HEALTHCARE · BIOTECHNOLOGY · USA

Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing and commercializing RNA interference (RNAi) therapies. The company is headquartered in Cambridge, Massachusetts.

Ascendis Pharma AS

HEALTHCARE · BIOTECHNOLOGY · USA

Ascendis Pharma A / S, a biopharmaceutical company, develops therapies for unmet medical needs. The company is headquartered in Hellerup, Denmark.

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