Xeris Pharmaceuticals Inc
NASDAQ: XERS · HEALTHCARE · DRUG MANUFACTURERS - SPECIALTY & GENERIC
Updated 2026-07-29
Xeris Pharmaceuticals Inc (XERS) Stock Valuation Analysis
Fair value estimate, historical valuation range, and quality signals for XERS.
Current price exceeds what fundamentals support. Risk/reward skewed unfavorably.
XERS historical valuation range
Where current P/E sits in XERS's own 5Y range.
XERS intrinsic value (DCF)
DCF-based fair value estimate vs current market price.
Standard discounted cash flow models produce unreliable output for unprofitable or near-breakeven companies. Revenue-based multiples such as P/S and EV/Sales, combined with the historical valuation position above, give a more reliable read for this stock.
Intrinsic value calculated using discounted cash flow (DCF) model based on projected free cash flows, discount rate, and terminal growth assumptions. A positive margin of safety indicates the current price is below estimated fair value, providing a cushion against estimation error.
XERS valuation signals
Quick-read green flags, caution flags, and risks based on current metrics.
P/E Ratio — History
Current: 125.43x
P/S Ratio — History
Current: 4.81x
Is XERS overvalued in 2026?
Xeris Pharmaceuticals Inc (XERS) currently trades at $8.38 per share with a market capitalization of $1,515,797,000.00. Based on our multi-factor framework, the stock appears richly valued with a Smart Value Score of 33/100. This score blends growth quality, financial health, and price attractiveness into a single institutional-grade read.
The stock trades at a P/E ratio of 125.4x, above its 5-year median of 103.4x.
Looking at its own history, XERS is currently trading more expensive than 83% of the last 5Y on P/E. This places it in the 83th percentile of its historical range, a zone where forward returns have typically been muted.
A standard DCF model does not produce reliable output for XERS under current conditions. For unprofitable or near-breakeven companies, revenue-based multiples such as EV/Sales and historical P/S percentile are more informative than intrinsic value calculations.
The Piotroski F-Score of 4/9 puts financial quality in a middling range, neither a standout strength nor an obvious red flag.
Bottom line: XERS appears richly valued on our framework, with a Smart Value Score of 33/100. At current levels the risk/reward is skewed against the buyer. A materially lower price or significant operational improvement would be needed to change the picture.
Frequently asked questions
Is XERS overvalued?
XERS scores 33/100 on our Smart Value Score (Grade F), a weak overall profile. A standard DCF is unreliable here given the profitability profile, so valuation leans on revenue-based measures like EV/Sales and the P/S percentile below.
What is XERS's fair value?
A standard DCF is unreliable for XERS given its current profitability profile. Revenue-based approaches like EV/Sales or the historical P/S percentile are more informative for this stock.
What P/E ratio does XERS trade at?
XERS trades at a P/E of 125.4x on trailing twelve-month earnings, against a 5-year median of 103.4x. P/E is what you pay per dollar of profit, and sitting above its own median means the stock is pricier than usual relative to its earnings.
Is XERS a buy based on valuation?
Our Smart Value rating for XERS is Strong Sell, from a Smart Value Score of 33/100 that blends growth, quality, and valuation. The profile skews cautious, and a better price or clearer operating improvement would strengthen the case. This is research to inform your decision, not personalized financial advice.
How does XERS's valuation compare to its history?
On P/E, XERS sits in the 83rd percentile of its own 5Y range, historically expensive relative to where it has traded. A high percentile means today's multiple is near the top of its historical band.
What is XERS's Smart Value Score?
XERS's Smart Value Score is 33/100. It is a proprietary WallStSmart metric blending growth quality, financial health, and valuation into a single 0-100 read, and scores above 75 are rare, signaling strong multi-factor alignment.