Vyne Therapeutics Inc
NASDAQ: VYNE · HEALTHCARE · BIOTECHNOLOGY
Updated 2026-05-06
Vyne Therapeutics Inc (VYNE) Stock Valuation Analysis
Fair value estimate, historical valuation range, and quality signals for VYNE.
Current price exceeds what fundamentals support. Risk/reward skewed unfavorably.
VYNE historical valuation range
Where current P/E sits in VYNE's own 5Y range.
VYNE intrinsic value (DCF)
DCF-based fair value estimate vs current market price.
Intrinsic value calculated using discounted cash flow (DCF) model based on projected free cash flows, discount rate, and terminal growth assumptions. A positive margin of safety indicates the current price is below estimated fair value, providing a cushion against estimation error.
VYNE valuation signals
Quick-read green flags, caution flags, and risks based on current metrics.
P/E Ratio — History
P/S Ratio — History
Current: 37.52x
Is VYNE overvalued in 2026?
Vyne Therapeutics Inc (VYNE) currently trades at $0.67 per share with a market capitalization of $21,385,900.00. Based on our multi-factor framework, the stock appears richly valued with a Smart Value Score of 34/100. This score blends growth quality, financial health, and price attractiveness into a single institutional-grade read.
VYNE currently has no meaningful P/E ratio, which typically signals that the company is unprofitable, near breakeven, or emerging from a loss-making period. With a P/S ratio of 37.5x, the market is valuing the company primarily on its revenue rather than its earnings.
Our discounted cash flow model estimates VYNE's intrinsic value at $0.87 per share, against the current market price of $0.67. This implies a margin of safety of +35.98%. A meaningful cushion exists against model error, making this a reasonable risk-adjusted entry.
Financial quality is a concern. The Piotroski F-Score of 0/9 flags weakening fundamentals that deserve closer scrutiny before the valuation case can be fully trusted.
Bottom line: VYNE appears richly valued on our framework, with a Smart Value Score of 34/100. At current levels the risk/reward is skewed against the buyer. A materially lower price or significant operational improvement would be needed to change the picture.
Frequently asked questions
Is VYNE overvalued in 2026?
Based on a Smart Value Score of 34/100, VYNE appears overvalued. Current price exceeds what fundamentals currently justify.
What is VYNE's fair value?
Our DCF model estimates VYNE's intrinsic value at $0.87 per share, versus the current price of $0.67. This produces a margin of safety of +35.98%.
What P/E ratio does VYNE trade at?
VYNE does not have a meaningful P/E ratio at this time, typically a sign of unprofitability or an ongoing earnings transition.
Is VYNE a buy based on valuation?
WallStSmart does not issue buy or sell recommendations. Our Smart Value Score of 34/100 reflects the combined read on growth, quality, and price. The profile skews cautious. Consider waiting for a better price or clearer operational improvement.
How does VYNE's valuation compare to its history?
Insufficient historical valuation data exists yet for a confident percentile read on VYNE.
What is VYNE's Smart Value Score?
VYNE's Smart Value Score is 34/100. The Smart Value Score is a proprietary WallStSmart metric blending growth quality, financial health, and valuation attractiveness into a single 0-100 read. Scores above 75 are rare and indicate strong multi-factor alignment.