Twist Bioscience Corp
NASDAQ: TWST · HEALTHCARE · DIAGNOSTICS & RESEARCH
Updated 2026-04-29
Twist Bioscience Corp (TWST) Stock Valuation Analysis
Fair value estimate, historical valuation range, and quality signals for TWST.
Current price exceeds what fundamentals support. Risk/reward skewed unfavorably.
TWST historical valuation range
Where current P/E sits in TWST's own 5Y range.
TWST intrinsic value (DCF)
DCF-based fair value estimate vs current market price.
Intrinsic value calculated using discounted cash flow (DCF) model based on projected free cash flows, discount rate, and terminal growth assumptions. A positive margin of safety indicates the current price is below estimated fair value, providing a cushion against estimation error.
TWST valuation signals
Quick-read green flags, caution flags, and risks based on current metrics.
P/E Ratio — History
P/S Ratio — History
Current: 8.88x
Is TWST overvalued in 2026?
Twist Bioscience Corp (TWST) currently trades at $56.70 per share with a market capitalization of $3,476,374,000.00. Based on our multi-factor framework, the stock appears richly valued with a Smart Value Score of 26/100. This score blends growth quality, financial health, and price attractiveness into a single institutional-grade read.
TWST currently has no meaningful P/E ratio, which typically signals that the company is unprofitable, near breakeven, or emerging from a loss-making period. With a P/S ratio of 8.9x, the market is valuing the company primarily on its revenue rather than its earnings.
Our discounted cash flow model estimates TWST's intrinsic value at $127.53 per share, against the current market price of $56.70. This implies a margin of safety of +61.08%. A meaningful cushion exists against model error, making this a reasonable risk-adjusted entry.
The Piotroski F-Score of 4/9 puts financial quality in a middling range, neither a standout strength nor an obvious red flag.
Bottom line: TWST appears richly valued on our framework, with a Smart Value Score of 26/100. At current levels the risk/reward is skewed against the buyer. A materially lower price or significant operational improvement would be needed to change the picture.
Frequently asked questions
Is TWST overvalued in 2026?
Based on a Smart Value Score of 26/100, TWST appears overvalued. Current price exceeds what fundamentals currently justify.
What is TWST's fair value?
Our DCF model estimates TWST's intrinsic value at $127.53 per share, versus the current price of $56.70. This produces a margin of safety of +61.08%.
What P/E ratio does TWST trade at?
TWST does not have a meaningful P/E ratio at this time, typically a sign of unprofitability or an ongoing earnings transition.
Is TWST a buy based on valuation?
WallStSmart does not issue buy or sell recommendations. Our Smart Value Score of 26/100 reflects the combined read on growth, quality, and price. The profile skews cautious. Consider waiting for a better price or clearer operational improvement.
How does TWST's valuation compare to its history?
Insufficient historical valuation data exists yet for a confident percentile read on TWST.
What is TWST's Smart Value Score?
TWST's Smart Value Score is 26/100. The Smart Value Score is a proprietary WallStSmart metric blending growth quality, financial health, and valuation attractiveness into a single 0-100 read. Scores above 75 are rare and indicate strong multi-factor alignment.