PYXS
Pyxis Oncology Inc
NASDAQ: PYXS · HEALTHCARE · BIOTECHNOLOGY
$1.98
+7.61% today
Updated 2026-10-28
Market cap
$200.69M
P/E ratio
—
P/S ratio
18.18x
EPS (TTM)
$-1.40
Dividend yield
—
52W range
$1 – $6
Volume
1.1M
Pyxis Oncology Inc (PYXS) Insider transactions
Net insider activity
Net buying (11,240,122 shares)
Buy transactions
81
Sell transactions
19
All transactions
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-08-20 | DUPONT, JAKOB | Director | Buy | 46,000 | — | — |
| 2026-08-12 | CIVIK, THOMAS | Director, Interim CEO | Buy | 250,956 | — | — |
| 2026-06-30 | DUPONT, JAKOB | Director | Sale | 35,000 | — | — |
| 2026-06-30 | DUPONT, JAKOB | Director | Buy | 35,000 | $1.60 | $56000.00 |
| 2026-03-24 | WADHANE, JITENDRA | Prin Fin & Acct Officer | Buy | 262,635 | — | — |
| 2026-03-24 | WADHANE, JITENDRA | Prin Fin & Acct Officer | Buy | 109,461 | — | — |
| 2026-03-24 | PALANI, SANTHOSH | Director | Buy | 45,867 | — | — |
| 2026-03-24 | METZGER, MICHAEL A | Director | Buy | 45,867 | — | — |
| 2026-03-24 | LEWIS-HALL, FREDA C | Director | Buy | 45,867 | — | — |
| 2026-03-24 | HUMPHREY, RACHEL | Director | Buy | 45,867 | — | — |
| 2026-03-24 | FLAVIN, JOHN L | Director | Buy | 45,867 | — | — |
| 2026-03-24 | DUPONT, JAKOB | Director | Buy | 45,867 | — | — |
| 2026-03-24 | CLINE, DARREN S | Director | Buy | 45,867 | — | — |
| 2026-02-03 | CIVIK, THOMAS | Director, Interim CEO | Buy | 690,131 | — | — |
| 2025-04-21 | HUMPHREY, RACHEL | Director | Sale | 13,896 | $1.03 | $14361.52 |
| 2025-04-17 | HUMPHREY, RACHEL | Director | Sale | 200 | $0.97 | $194.00 |
| 2025-04-14 | HUMPHREY, RACHEL | Director | Sale | 1,400 | $0.97 | $1361.78 |
| 2025-03-31 | WADHANE, JITENDRA | SVP, Chief Accounting Officer | Buy | 263,782 | $0.98 | $258506.36 |
| 2025-03-31 | SULLIVAN, LARA | Director, President ,CEO & CMO | Buy | 918,308 | $0.98 | $899941.84 |
| 2025-03-31 | PALANI, SANTHOSH | Director | Buy | 36,979 | $0.98 | $36239.42 |
| 2025-03-31 | METZGER, MICHAEL A | Director | Buy | 36,979 | $0.98 | $36239.42 |
| 2025-03-31 | LEWIS-HALL, FREDA C | Director | Buy | 36,979 | $0.98 | $36239.42 |
| 2025-03-31 | HUMPHREY, RACHEL | Director | Buy | 36,979 | $0.98 | $36239.42 |
| 2025-03-31 | FLAVIN, JOHN L | Director | Buy | 36,979 | $0.98 | $36239.42 |
| 2025-03-31 | DUPONT, JAKOB | Director | Buy | 36,979 | $0.98 | $36239.42 |
| 2025-03-31 | CONNEALY, PAMELA ANN | CFO & COO | Buy | 414,163 | $0.98 | $405879.74 |
| 2025-03-31 | CLINE, DARREN S | Director | Buy | 36,979 | $0.98 | $36239.42 |
| 2025-03-31 | CIVIK, THOMAS | Director | Buy | 36,979 | $0.98 | $36239.42 |
| 2024-12-23 | WADHANE, JITENDRA | SVP, Chief Accounting Officer | Buy | 150,000 | — | — |
| 2024-12-23 | SULLIVAN, LARA | Director, Chief Executive Officer | Buy | 1,135,000 | — | — |
| 2024-12-23 | CONNEALY, PAMELA ANN | CFO & COO | Buy | 310,000 | — | — |
| 2024-11-26 | CONNEALY, PAMELA ANN | CFO & COO | Buy | 83,400 | $1.96 | $163464.00 |
| 2024-11-26 | CONNEALY, PAMELA ANN | CFO & COO | Buy | 5,450 | $2.00 | $10900.00 |
| 2024-06-10 | METZGER, MICHAEL A | Director | Buy | 70,683 | — | — |
| 2024-06-07 | PALANI, SANTHOSH | Director | Buy | 6,000 | — | — |
| 2024-03-26 | WADHANE, JITENDRA | SVP, Chief Accounting Officer | Buy | 131,484 | — | — |
| 2024-03-26 | SULLIVAN, LARA | Director, Chief Executive Officer | Buy | 1,071,242 | $3.83 | $4.10M |
| 2024-03-26 | LEWIS-HALL, FREDA C | Director | Buy | 35,219 | — | — |
| 2024-03-26 | HUMPHREY, RACHEL | Director | Buy | 38,741 | — | — |
| 2024-03-26 | FLAVIN, JOHN L | Director | Buy | 35,219 | — | — |
| 2024-03-26 | DUPONT, JAKOB | Director | Buy | 38,741 | — | — |
| 2024-03-26 | CONNEALY, PAMELA ANN | CFO & COO | Buy | 328,710 | — | — |
| 2024-03-26 | CLINE, DARREN S | Director | Buy | 35,219 | — | — |
| 2024-03-26 | CIVIK, THOMAS | Director | Buy | 44,024 | $3.83 | $168611.92 |
| 2024-03-12 | PALANI, SANTHOSH | Director | Buy | 69,760 | — | — |
| 2023-12-29 | KOBAYASHI, KEN | Chief Medical Officer | Buy | 443,514 | — | — |
| 2023-12-29 | KOBAYASHI, KEN | Chief Medical Officer | Buy | 110,878 | — | — |
| 2023-11-29 | CONNEALY, PAMELA ANN | CFO and COO | Sale | 36,949 | $1.40 | $51728.60 |
| 2023-11-15 | WADHANE, JITENDRA | Chief Accounting Officer | Buy | 40,000 | — | — |
| 2023-09-28 | CONNEALY, PAMELA ANN | CFO and COO | Buy | 8,000 | $1.87 | $14960.00 |
| 2023-09-27 | WADHANE, JITENDRA | Chief Accounting Officer | Buy | 2,500 | $1.87 | $4675.00 |
| 2023-09-27 | CONNEALY, PAMELA ANN | CFO and COO | Buy | 6,426 | $1.85 | $11867.54 |
| 2023-09-25 | WADHANE, JITENDRA | Chief Accounting Officer | Buy | 5,000 | $1.77 | $8850.00 |
| 2023-09-25 | CONNEALY, PAMELA ANN | CFO and COO | Buy | 12,000 | $1.67 | $20043.60 |
| 2023-09-22 | WADHANE, JITENDRA | Chief Accounting Officer | Buy | 2,500 | $1.74 | $4349.25 |
| 2023-09-22 | DUPONT, JAKOB | Director | Buy | 392,461 | — | — |
| 2023-09-22 | CONNEALY, PAMELA ANN | CFO and COO | Buy | 5,000 | $1.74 | $8695.00 |
| 2023-09-18 | SULLIVAN, LARA | Director, President and CEO | Sale | 8,541 | $2.10 | $17936.10 |
| 2023-09-14 | SULLIVAN, LARA | Director, President and CEO | Sale | 100 | $2.25 | $225.00 |
| 2023-09-13 | SULLIVAN, LARA | Director, President and CEO | Sale | 184,742 | $2.13 | $393500.46 |
| 2023-09-13 | SULLIVAN, LARA | Director, President and CEO | Sale | 3,000 | $2.27 | $6815.70 |
| 2023-09-12 | SULLIVAN, LARA | Director, President and CEO | Sale | 4,917 | $2.25 | $11071.12 |
| 2023-09-11 | SULLIVAN, LARA | Director, President and CEO | Sale | 20,000 | $2.27 | $45414.00 |
| 2023-09-07 | WADHANE, JITENDRA | Chief Accounting Officer | Buy | 93,896 | — | — |
| 2023-09-07 | SULLIVAN, LARA | Director, President and CEO | Buy | 469,483 | — | — |
| 2023-09-07 | CONNEALY, PAMELA ANN | CFO and COO | Buy | 187,793 | — | — |
| 2023-08-23 | DUPONT, JAKOB | Director | Buy | 17,250 | — | — |
| 2023-08-23 | DUPONT, JAKOB | Director | Buy | 5,879 | — | — |
| 2023-08-23 | DUPONT, JAKOB | Director | Buy | 3,534 | — | — |
| 2023-03-24 | YANCHIK, CONNEALY PAMELA | CFO and COO | Sale | 322,265 | — | — |
| 2023-03-24 | YANCHIK, CONNEALY PAMELA | CFO and COO | Sale | 10,304 | — | — |
| 2023-03-24 | YANCHIK, CONNEALY PAMELA | CFO and COO | Buy | 209,803 | — | — |
| 2023-03-24 | WADHANE, JITENDRA | Chief Accounting Officer | Sale | 157,257 | — | — |
| 2023-03-24 | WADHANE, JITENDRA | Chief Accounting Officer | Buy | 45,000 | — | — |
| 2023-03-24 | WADHANE, JITENDRA | Chief Accounting Officer | Buy | 29,393 | — | — |
| 2023-03-24 | SULLIVAN, LARA | Director, President and CEO | Sale | 990,461 | — | — |
| 2023-03-24 | SULLIVAN, LARA | Director, President and CEO | Sale | 61,825 | — | — |
| 2023-03-24 | SULLIVAN, LARA | Director, President and CEO | Buy | 703,379 | — | — |
| 2023-03-24 | LEWIS-HALL, FREDA C | Director | Buy | 139,355 | — | — |
| 2023-03-24 | HUMPHREY, RACHEL | Director | Buy | 58,064 | — | — |
| 2023-03-24 | FLAVIN, JOHN L | Director | Buy | 139,355 | — | — |
| 2023-03-24 | FEINGOLD, JAY | Chief Medical Officer | Sale | 157,257 | — | — |
| 2023-03-24 | FEINGOLD, JAY | Chief Medical Officer | Sale | 17,517 | — | — |
| 2023-03-24 | FEINGOLD, JAY | Chief Medical Officer | Buy | 209,803 | — | — |
| 2023-03-24 | CLINE, DARREN S | Director | Buy | 139,355 | — | — |
| 2023-03-24 | CIVIK, THOMAS | Director | Buy | 139,355 | — | — |
| 2023-03-17 | PFIZER, INC | 10% Owner | Buy | 1,811,594 | $2.76 | $5.00M |
| 2023-01-03 | YANCHIK, CONNEALY PAMELA | Chief Financial Officer | Buy | 43,493 | — | — |
| 2023-01-03 | SULLIVAN, LARA | Director, Chief Executive Officer | Buy | 95,684 | — | — |
| 2023-01-03 | FEINGOLD, JAY | Chief Medical Officer | Buy | 53,931 | — | — |
| 2022-08-11 | HUMPHREY, RACHEL | Director | Buy | 236,220 | — | — |
| 2022-04-21 | CHIN, MARK | Former Director | Sale | 1,745,761 | $3.05 | $5.32M |
| 2022-04-14 | YANCHIK, CONNEALY PAMELA | Chief Financial Officer | Buy | 93,493 | — | — |
| 2022-04-14 | SULLIVAN, LARA | Director, Chief Executive Officer | Buy | 315,273 | — | — |
| 2022-04-14 | FEINGOLD, JAY | Chief Medical Officer | Buy | 115,931 | — | — |
| 2022-03-31 | YANCHIK, CONNEALY PAMELA | Chief Financial Officer | Buy | 247,524 | — | — |
| 2022-03-31 | SULLIVAN, LARA | Director, Chief Executive Officer | Buy | 742,574 | — | — |
| 2022-03-31 | LEWIS-HALL, FREDA C | Director | Buy | 66,831 | — | — |
| 2022-03-31 | FLAVIN, JOHN L | Director | Buy | 66,831 | — | — |
| 2022-03-31 | FEINGOLD, JAY | Chief Medical Officer | Buy | 306,930 | — | — |
Frequently asked questions
Are PYXS insiders buying or selling?
Over the transactions on record, PYXS insiders have been net buyers, with about $5.87M in stock sold across 19 sales, against 24 open-market purchases.
Does insider selling at PYXS mean the stock will fall?
Not by itself. Most executive selling is pre-scheduled through 10b5-1 plans filed months in advance, and insiders sell for diversification, taxes, and liquidity far more often than out of any view on the price. Insider buying is the stronger signal, especially when several insiders buy around the same time, because there is usually only one reason to put personal cash into the stock.
Which PYXS insiders are selling the most?
Recent selling is concentrated in a few names. CHIN, MARK accounts for the largest share on record, with about $5.32M sold. Selling by one or two individuals matters less than broad selling across the whole leadership team, which is the pattern worth watching.