PTGX
Protagonist Therapeutics Inc
NASDAQ: PTGX · HEALTHCARE · BIOTECHNOLOGY
$142.14
+0.72% today
Updated 2026-10-28
Market cap
$8.33B
P/E ratio
125.00
P/S ratio
29.54x
EPS (TTM)
$1.03
Dividend yield
—
52W range
$73 – $161
Volume
0.7M
Protagonist Therapeutics Inc (PTGX) Insider transactions
Net insider activity
Net selling (269,267 shares)
Buy transactions
39
Sell transactions
61
All transactions
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-09-30 | ALI, ASIF | Chief Financial Officer | Sale | 28,438 | — | — |
| 2026-09-30 | ALI, ASIF | Chief Financial Officer | Sale | 15,650 | — | — |
| 2026-09-30 | ALI, ASIF | Chief Financial Officer | Sale | 9,229 | — | — |
| 2026-09-30 | ALI, ASIF | Chief Financial Officer | Sale | 5,312 | — | — |
| 2026-09-30 | ALI, ASIF | Chief Financial Officer | Sale | 46,034 | $141.78 | $6.53M |
| 2026-09-30 | ALI, ASIF | Chief Financial Officer | Buy | 28,438 | $23.42 | $666017.96 |
| 2026-09-30 | ALI, ASIF | Chief Financial Officer | Buy | 15,650 | $19.19 | $300323.50 |
| 2026-09-30 | ALI, ASIF | Chief Financial Officer | Sale | 12,595 | $141.77 | $1.79M |
| 2026-09-30 | ALI, ASIF | Chief Financial Officer | Buy | 9,229 | $38.98 | $359746.42 |
| 2026-09-30 | ALI, ASIF | Chief Financial Officer | Buy | 5,312 | $12.17 | $64647.04 |
| 2026-09-10 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 7,278 | — | — |
| 2026-09-10 | PATEL, DINESH V PH D | Director, President and CEO | Buy | 7,278 | $21.58 | $157059.24 |
| 2026-09-09 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 63,548 | — | — |
| 2026-09-09 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 63,548 | $146.18 | $9.29M |
| 2026-09-08 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 54,174 | — | — |
| 2026-09-08 | PATEL, DINESH V PH D | Director, President and CEO | Buy | 54,174 | $21.58 | $1.17M |
| 2026-09-03 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 510 | — | — |
| 2026-08-11 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 34,239 | — | — |
| 2026-08-11 | PATEL, DINESH V PH D | Director, President and CEO | Buy | 34,239 | $21.58 | $738877.62 |
| 2026-08-10 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 65,761 | — | — |
| 2026-08-10 | PATEL, DINESH V PH D | Director, President and CEO | Buy | 65,761 | $21.58 | $1.42M |
| 2026-06-23 | WADDILL, WILLIAM D. | Director | Sale | 9,000 | — | — |
| 2026-06-23 | WADDILL, WILLIAM D. | Director | Sale | 9,000 | $117.94 | $1.06M |
| 2026-06-10 | WADDILL, WILLIAM D. | Director | Sale | 6,000 | — | — |
| 2026-06-10 | WADDILL, WILLIAM D. | Director | Sale | 3,000 | — | — |
| 2026-06-10 | WADDILL, WILLIAM D. | Director | Sale | 9,000 | $107.68 | $969120.00 |
| 2026-06-10 | WADDILL, WILLIAM D. | Director | Buy | 6,000 | $16.54 | $99240.00 |
| 2026-06-10 | WADDILL, WILLIAM D. | Director | Buy | 3,000 | $11.80 | $35400.00 |
| 2026-05-29 | WADDILL, WILLIAM D. | Director | Sale | 9,000 | — | — |
| 2026-05-29 | WADDILL, WILLIAM D. | Director | Sale | 9,000 | $99.64 | $896760.00 |
| 2026-05-12 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 75,000 | — | — |
| 2026-05-12 | PATEL, DINESH V PH D | Director, President and CEO | Buy | 75,000 | $21.58 | $1.62M |
| 2026-05-08 | GIRAUDO, BRYAN | Director | Sale | 6,000 | $100.00 | $600000.00 |
| 2026-05-08 | GIRAUDO, BRYAN | Director | Sale | 5,130 | $100.00 | $513000.00 |
| 2026-05-07 | GIRAUDO, BRYAN | Director | Sale | 24,000 | — | — |
| 2026-05-07 | GIRAUDO, BRYAN | Director | Sale | 12,000 | — | — |
| 2026-05-07 | GIRAUDO, BRYAN | Director | Sale | 36,000 | $100.14 | $3.61M |
| 2026-05-07 | GIRAUDO, BRYAN | Director | Buy | 24,000 | $6.45 | $154800.00 |
| 2026-05-07 | GIRAUDO, BRYAN | Director | Buy | 12,000 | $6.98 | $83760.00 |
| 2026-04-23 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 1,460 | — | — |
| 2026-04-20 | ALI, ASIF | Chief Financial Officer | Sale | 1,750 | $105.47 | $184572.50 |
| 2026-03-26 | SELICK, HAROLD E | Director | Sale | 24,000 | — | — |
| 2026-03-26 | SELICK, HAROLD E | Director | Sale | 24,000 | $105.00 | $2.52M |
| 2026-03-26 | MOLINA, ARTURO MD | Chief Medical Officer | Sale | 15,000 | — | — |
| 2026-03-26 | MOLINA, ARTURO MD | Chief Medical Officer | Sale | 15,000 | $104.79 | $1.57M |
| 2026-03-26 | ALI, ASIF | Chief Financial Officer | Sale | 19,500 | — | — |
| 2026-03-26 | ALI, ASIF | Chief Financial Officer | Sale | 5,265 | — | — |
| 2026-03-26 | ALI, ASIF | Chief Financial Officer | Sale | 24,765 | $104.24 | $2.58M |
| 2026-03-26 | ALI, ASIF | Chief Financial Officer | Buy | 19,500 | $19.19 | $374205.00 |
| 2026-03-26 | ALI, ASIF | Chief Financial Officer | Buy | 5,265 | $12.17 | $64075.05 |
| 2026-03-25 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 54,641 | — | — |
| 2026-03-25 | PATEL, DINESH V PH D | Director, President and CEO | Buy | 54,641 | $8.58 | $468819.78 |
| 2026-03-24 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 59 | — | — |
| 2026-03-24 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 59 | $101.00 | $5959.00 |
| 2026-03-23 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 50,000 | — | — |
| 2026-02-17 | WILLIAMS, LEWIS T | Director | Buy | 18,000 | — | — |
| 2026-02-17 | WILLIAMS, LEWIS T | Director | Sale | 18,000 | $82.42 | $1.48M |
| 2026-02-06 | WADDILL, WILLIAM D. | Director | Sale | 20,000 | — | — |
| 2026-02-06 | WADDILL, WILLIAM D. | Director | Buy | 20,000 | $8.31 | $166200.00 |
| 2026-01-27 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 4,068 | — | — |
| 2026-01-27 | PATEL, DINESH V PH D | Director, President and CEO | Buy | 4,068 | $21.58 | $87787.44 |
| 2026-01-27 | MOLINA, ARTURO MD | Chief Medical Officer | Sale | 5,000 | — | — |
| 2026-01-27 | MOLINA, ARTURO MD | Chief Medical Officer | Sale | 5,000 | $82.00 | $410000.00 |
| 2026-01-27 | ALI, ASIF | Chief Financial Officer | Sale | 16,000 | — | — |
| 2026-01-27 | ALI, ASIF | Chief Financial Officer | Sale | 12,000 | — | — |
| 2026-01-27 | ALI, ASIF | Chief Financial Officer | Sale | 28,000 | $83.13 | $2.33M |
| 2026-01-27 | ALI, ASIF | Chief Financial Officer | Sale | 18,203 | $83.14 | $1.51M |
| 2026-01-27 | ALI, ASIF | Chief Financial Officer | Buy | 16,000 | $19.19 | $307040.00 |
| 2026-01-27 | ALI, ASIF | Chief Financial Officer | Buy | 12,000 | $12.17 | $146040.00 |
| 2026-01-26 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 14,205 | — | — |
| 2026-01-26 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 10,685 | — | — |
| 2026-01-26 | PATEL, DINESH V PH D | Director, President and CEO | Buy | 14,205 | $21.58 | $306543.90 |
| 2026-01-26 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 10,685 | $84.00 | $897540.00 |
| 2026-01-26 | MOLINA, ARTURO MD | Chief Medical Officer | Sale | 5,000 | — | — |
| 2026-01-26 | MOLINA, ARTURO MD | Chief Medical Officer | Sale | 5,000 | $82.28 | $411400.00 |
| 2026-01-23 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 19,315 | — | — |
| 2026-01-23 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 19,315 | $84.59 | $1.63M |
| 2026-01-23 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 6,000 | — | — |
| 2026-01-23 | MOLINA, ARTURO MD | Chief Medical Officer | Sale | 13,151 | $82.42 | $1.08M |
| 2026-01-20 | PATEL, DINESH V PH D | Director, President and CEO | Sale | 34,438 | $82.48 | $2.84M |
| 2026-01-20 | MOLINA, ARTURO MD | Chief Medical Officer | Sale | 9,514 | $82.48 | $784714.72 |
| 2026-01-20 | ALI, ASIF | Chief Financial Officer | Sale | 8,588 | $82.48 | $708338.24 |
| 2026-01-09 | SELICK, HAROLD E | Director | Sale | 14,299 | — | — |
| 2026-01-09 | SELICK, HAROLD E | Director | Buy | 14,299 | $4.21 | $60198.79 |
| 2026-01-02 | WILLIAMS, LEWIS T | Director | Buy | 3,762 | — | — |
| 2026-01-02 | WILLIAMS, LEWIS T | Director | Buy | 2,695 | — | — |
| 2026-01-02 | WADDILL, WILLIAM D. | Director | Buy | 3,762 | — | — |
| 2026-01-02 | WADDILL, WILLIAM D. | Director | Buy | 2,695 | — | — |
| 2026-01-02 | SELICK, HAROLD E | Director | Buy | 3,762 | — | — |
| 2026-01-02 | SELICK, HAROLD E | Director | Buy | 2,695 | — | — |
| 2026-01-02 | PATEL, DINESH V PH D | Director, President and CEO | Buy | 120,200 | — | — |
| 2026-01-02 | PATEL, DINESH V PH D | Director, President and CEO | Buy | 95,400 | — | — |
| 2026-01-02 | O'DOWD, SARAH A | Director | Buy | 3,762 | — | — |
| 2026-01-02 | O'DOWD, SARAH A | Director | Buy | 2,695 | — | — |
| 2026-01-02 | MOLINA, ARTURO MD | Chief Medical Officer | Buy | 32,000 | — | — |
| 2026-01-02 | MOLINA, ARTURO MD | Chief Medical Officer | Buy | 25,600 | — | — |
| 2026-01-02 | GIRAUDO, BRYAN | Director | Buy | 3,762 | — | — |
| 2026-01-02 | GIRAUDO, BRYAN | Director | Buy | 2,695 | — | — |
| 2026-01-02 | ALI, ASIF | Chief Financial Officer | Buy | 32,000 | — | — |
| 2026-01-02 | ALI, ASIF | Chief Financial Officer | Buy | 25,600 | — | — |
Frequently asked questions
Are PTGX insiders buying or selling?
Over the transactions on record, PTGX insiders have been net sellers, with about $46.21M in stock sold across 61 sales, against 22 open-market purchases.
Does insider selling at PTGX mean the stock will fall?
Not by itself. Most executive selling is pre-scheduled through 10b5-1 plans filed months in advance, and insiders sell for diversification, taxes, and liquidity far more often than out of any view on the price. Insider buying is the stronger signal, especially when several insiders buy around the same time, because there is usually only one reason to put personal cash into the stock.
Which PTGX insiders are selling the most?
Recent selling is concentrated in a few names. ALI, ASIF accounts for the largest share on record, with about $15.63M sold. Selling by one or two individuals matters less than broad selling across the whole leadership team, which is the pattern worth watching.