PRLD
Prelude Therapeutics Inc
NASDAQ: PRLD · HEALTHCARE · BIOTECHNOLOGY
$4.80
+11.48% today
Updated 2026-06-04
Market cap
$314.60M
P/E ratio
—
P/S ratio
18.77x
EPS (TTM)
$-1.00
Dividend yield
—
52W range
$1 – $6
Volume
0.4M
Prelude Therapeutics Inc (PRLD) Insider transactions
Net insider activity
Net buying (35,561,899 shares)
Buy transactions
82
Sell transactions
18
All transactions
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-05-01 | MORRIS, CHARLES Q | Chief Medical Officer | Buy | 450,000 | $4.70 | $2.12M |
| 2026-04-27 | RA, CAPITAL MANAGEMENT, L.P. | 10% Owner | Buy | 1,407,000 | — | — |
| 2026-04-27 | RA, CAPITAL MANAGEMENT, L.P. | 10% Owner | Sale | 1,407,000 | — | — |
| 2026-04-21 | ORBIMED, ADVISORS LLC | Director, 10% Owner | Buy | 1,689,189 | $4.44 | $7.50M |
| 2026-04-21 | ORBIMED, ADVISORS LLC | Director, 10% Owner | Buy | 1,126,126 | $4.44 | $5.00M |
| 2026-04-21 | BONITA, DAVID P | Director, 10% Owner | Buy | 1,689,189 | $4.44 | $7.50M |
| 2026-04-21 | BONITA, DAVID P | Director, 10% Owner | Buy | 1,126,126 | $4.44 | $5.00M |
| 2026-04-21 | BAKER, BROS. ADVISORS LP | Director, 10% Owner | Buy | 2,137,651 | $4.44 | $9.49M |
| 2026-04-21 | BAKER, BROS. ADVISORS LP | Director, 10% Owner | Buy | 114,601 | $4.44 | $508816.98 |
| 2026-02-04 | VADDI, KRISHNA | Director, CEO | Buy | 837,000 | — | — |
| 2026-02-04 | SCHERLE, PEGGY | Chief Scientific Officer | Buy | 230,000 | — | — |
| 2026-02-04 | LIM, BRYANT DAVID | CLO, CFO, Corp Sec. | Buy | 275,000 | — | — |
| 2026-02-04 | COMBS, ANDREW | Chief Chemistry Officer | Buy | 230,000 | — | — |
| 2025-11-05 | SANDOR, VICTOR | Director | Buy | 121,285 | — | — |
| 2025-10-17 | DORTON, KATINA | Director | Buy | 76,000 | — | — |
| 2025-10-04 | HUANG, JANE | President, CMO | Sale | 9,375 | — | — |
| 2025-10-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2025-10-04 | HUANG, JANE | President, CMO | Sale | 3,355 | $1.47 | $4931.85 |
| 2025-07-04 | HUANG, JANE | President, CMO | Sale | 9,375 | — | — |
| 2025-07-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2025-07-04 | HUANG, JANE | President, CMO | Sale | 3,355 | $0.79 | $2663.53 |
| 2025-06-12 | SANDOR, VICTOR | Director | Buy | 38,000 | — | — |
| 2025-06-12 | FRIEDMAN, PAUL A | Director | Buy | 38,000 | — | — |
| 2025-06-12 | DIER, MARDI | Director | Buy | 38,000 | — | — |
| 2025-06-12 | BONITA, DAVID P | Director, 10% Owner | Buy | 38,000 | — | — |
| 2025-06-12 | BAKER, BROS. ADVISORS LP | Director, 10% Owner | Buy | 76,000 | — | — |
| 2025-06-12 | BABLER, MARTIN | Director | Buy | 38,000 | — | — |
| 2025-04-04 | HUANG, JANE | President, CMO | Sale | 9,375 | — | — |
| 2025-04-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2025-04-04 | HUANG, JANE | President, CMO | Sale | 3,355 | $0.68 | $2264.63 |
| 2025-03-25 | VADDI, KRISHNA | Director, CEO | Buy | 675,000 | $0.69 | $467437.50 |
| 2025-03-25 | COMBS, ANDREW | Chief Chemistry Officer | Buy | 100,000 | $0.69 | $69250.00 |
| 2025-03-21 | VADDI, KRISHNA | Director, CEO | Buy | 15,000 | $0.73 | $10959.00 |
| 2025-03-20 | VADDI, KRISHNA | Director, CEO | Buy | 5,416 | $0.73 | $3950.43 |
| 2025-03-17 | VADDI, KRISHNA | Director, CEO | Buy | 9,106 | $0.75 | $6828.59 |
| 2025-03-14 | VADDI, KRISHNA | Director, CEO | Buy | 29,999 | $0.75 | $22631.25 |
| 2025-03-13 | VADDI, KRISHNA | Director, CEO | Buy | 50,000 | $0.72 | $35820.00 |
| 2025-03-12 | VADDI, KRISHNA | Director, CEO | Buy | 47,500 | $0.71 | $33744.00 |
| 2025-02-04 | VADDI, KRISHNA | Director, CEO | Buy | 496,000 | — | — |
| 2025-02-04 | SCHERLE, PEGGY | Chief Scientific Officer | Buy | 175,000 | — | — |
| 2025-02-04 | LIM, BRYANT DAVID | CLO, CFO, Corp Sec. | Buy | 200,000 | — | — |
| 2025-02-04 | HUANG, JANE | President, CMO | Buy | 200,000 | — | — |
| 2025-02-04 | COMBS, ANDREW | Chief Chemistry Officer | Buy | 175,000 | — | — |
| 2025-01-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2025-01-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2025-01-04 | HUANG, JANE | President, CMO | Sale | 3,859 | $1.39 | $5364.01 |
| 2024-12-31 | VADDI, KRISHNA | Director, CEO | Buy | 5,000 | $1.21 | $6043.50 |
| 2024-12-30 | VADDI, KRISHNA | Director, CEO | Buy | 10,000 | $1.20 | $12000.00 |
| 2024-12-23 | COMBS, ANDREW | Chief Chemistry Officer | Buy | 60,000 | $1.37 | $82002.00 |
| 2024-12-20 | COMBS, ANDREW | Chief Chemistry Officer | Buy | 3,075 | $1.15 | $3536.25 |
| 2024-12-19 | VADDI, KRISHNA | Director, CEO | Buy | 6,888 | $0.89 | $6115.86 |
| 2024-12-19 | LIM, BRYANT DAVID | CLO, Interim CFO, Corp Sec. | Buy | 25,000 | $0.91 | $22637.50 |
| 2024-12-18 | VADDI, KRISHNA | Director, CEO | Buy | 100,000 | $0.93 | $93210.00 |
| 2024-10-04 | HUANG, JANE | President, CMO | Sale | 9,375 | — | — |
| 2024-10-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2024-10-04 | HUANG, JANE | President, CMO | Sale | 3,349 | $2.00 | $6698.00 |
| 2024-07-04 | HUANG, JANE | President, CMO | Sale | 9,375 | — | — |
| 2024-07-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2024-07-04 | HUANG, JANE | President, CMO | Sale | 3,347 | $3.60 | $12049.20 |
| 2024-06-14 | SANDOR, VICTOR | Director | Buy | 23,500 | — | — |
| 2024-06-14 | FRIEDMAN, PAUL A | Director | Buy | 23,500 | — | — |
| 2024-06-14 | DIER, MARDI | Director | Buy | 23,500 | — | — |
| 2024-06-14 | BONITA, DAVID P | Director, 10% Owner | Buy | 23,500 | — | — |
| 2024-06-14 | BAKER, BROS. ADVISORS LP | Director, 10% Owner | Buy | 23,500 | — | — |
| 2024-06-14 | BABLER, MARTIN | Director | Buy | 23,500 | — | — |
| 2024-05-14 | LIM, BRYANT DAVID | CLO, Interim CFO, Corp Sec. | Buy | 25,000 | — | — |
| 2024-04-04 | HUANG, JANE | President, CMO | Sale | 9,375 | — | — |
| 2024-04-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2024-04-04 | HUANG, JANE | President, CMO | Sale | 3,347 | $4.74 | $15864.78 |
| 2024-03-01 | VADDI, KRISHNA | Director, CEO | Buy | 425,000 | — | — |
| 2024-03-01 | SCHERLE, PEGGY | Chief Scientific Officer | Buy | 150,000 | — | — |
| 2024-03-01 | LIM, BRYANT DAVID | Chief Legal Officer, Corp Sec. | Buy | 150,000 | — | — |
| 2024-03-01 | HUANG, JANE | President, CMO | Buy | 175,000 | — | — |
| 2024-03-01 | COMBS, ANDREW | Chief Chemistry Officer | Buy | 150,000 | — | — |
| 2024-03-01 | CHARDONNET, LAURENT | Chief Financial Officer | Buy | 150,000 | — | — |
| 2024-01-04 | HUANG, JANE | President, CMO | Sale | 9,375 | — | — |
| 2024-01-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2024-01-04 | HUANG, JANE | President, CMO | Sale | 3,844 | $3.77 | $14491.88 |
| 2023-12-13 | BAKER, BROS. ADVISORS LP | Director, 10% Owner | Buy | 7,343,307 | $3.15 | $23.13M |
| 2023-12-13 | BAKER, BROS. ADVISORS LP | Director, 10% Owner | Buy | 593,452 | $3.15 | $1.87M |
| 2023-10-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2023-10-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2023-07-04 | HUANG, JANE | President, CMO | Sale | 9,375 | — | — |
| 2023-07-04 | HUANG, JANE | President, CMO | Buy | 9,375 | — | — |
| 2023-07-04 | HUANG, JANE | President, CMO | Sale | 3,242 | $4.65 | $15075.30 |
| 2023-06-16 | SANDOR, VICTOR | Director | Buy | 23,500 | — | — |
| 2023-06-16 | FRIEDMAN, PAUL A | Director | Buy | 23,500 | — | — |
| 2023-06-16 | DIER, MARDI | Director | Buy | 23,500 | — | — |
| 2023-06-16 | BONITA, DAVID P | Director, 10% Owner | Buy | 23,500 | — | — |
| 2023-06-16 | BAKER, BROS. ADVISORS LP | Director, 10% Owner | Buy | 23,500 | — | — |
| 2023-06-16 | BABLER, MARTIN | Director | Buy | 23,500 | — | — |
| 2023-05-25 | VADDI, KRISHNA | Director, CEO | Buy | 900 | $5.31 | $4779.00 |
| 2023-05-24 | VADDI, KRISHNA | Director, CEO | Buy | 1,000 | $5.01 | $5011.40 |
| 2023-05-24 | LIM, BRYANT DAVID | Chief Legal Officer, Corp Sec. | Buy | 2,400 | $5.39 | $12936.00 |
| 2023-05-23 | VADDI, KRISHNA | Director, CEO | Buy | 11,856 | $5.63 | $66749.28 |
| 2023-05-23 | CHARDONNET, LAURENT | Chief Financial Officer | Buy | 5,000 | $5.50 | $27500.00 |
| 2023-05-22 | ORBIMED, ADVISORS LLC | Director, 10% Owner | Buy | 869,565 | $5.75 | $5.00M |
| 2023-05-22 | BONITA, DAVID P | Director, 10% Owner | Buy | 869,565 | $5.75 | $5.00M |
| 2023-05-22 | BAKER, BROS. ADVISORS LP | Director, 10% Owner | Buy | 10,625,036 | $5.75 | $61.09M |
| 2023-05-22 | BAKER, BROS. ADVISORS LP | Director, 10% Owner | Buy | 970,220 | $5.75 | $5.58M |
Frequently asked questions
Are PRLD insiders buying or selling?
Over the transactions on record, PRLD insiders have been net buyers, with about $79403.18 in stock sold across 18 sales, against 33 open-market purchases.
Does insider selling at PRLD mean the stock will fall?
Not by itself. Most executive selling is pre-scheduled through 10b5-1 plans filed months in advance, and insiders sell for diversification, taxes, and liquidity far more often than out of any view on the price. Insider buying is the stronger signal, especially when several insiders buy around the same time, because there is usually only one reason to put personal cash into the stock.
Which PRLD insiders are selling the most?
Recent selling is concentrated in a few names. HUANG, JANE accounts for the largest share on record, with about $79403.18 sold. Selling by one or two individuals matters less than broad selling across the whole leadership team, which is the pattern worth watching.