PRAX
Praxis Precision Medicines Inc
NASDAQ: PRAX · HEALTHCARE · BIOTECHNOLOGY
$285.48
+6.69% today
Updated 2026-10-28
Market cap
$6.75B
P/E ratio
—
P/S ratio
144.69x
EPS (TTM)
$-12.95
Dividend yield
—
52W range
$154 – $393
Volume
0.5M
Praxis Precision Medicines Inc (PRAX) Insider transactions
Net insider activity
Net buying (310,966 shares)
Buy transactions
53
Sell transactions
47
All transactions
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-07-08 | SOUZA, MARCIO | Director, Chief Executive Officer | Sale | 20,521 | — | — |
| 2026-07-08 | SOUZA, MARCIO | Director, Chief Executive Officer | Sale | 2,600 | — | — |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 8,566 | — | — |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 3,034 | — | — |
| 2026-06-24 | DESIMONE, JILL | Director | Buy | 8,566 | $44.25 | $379045.50 |
| 2026-06-24 | DESIMONE, JILL | Director | Buy | 3,034 | $147.30 | $446908.20 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 2,854 | $311.91 | $890202.56 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 1,750 | $310.89 | $544055.75 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 1,279 | $314.90 | $402758.38 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 1,240 | $308.24 | $382221.32 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 1,004 | $312.83 | $314081.32 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 999 | $309.38 | $309073.62 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 837 | $315.71 | $264245.08 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 683 | $306.77 | $209521.86 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 504 | $313.66 | $158086.15 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 320 | $305.31 | $97699.20 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 120 | $303.13 | $36375.24 |
| 2026-06-24 | DESIMONE, JILL | Director | Sale | 10 | $301.44 | $3014.40 |
| 2026-06-10 | YOUNG, WILLIAM D | Director | Buy | 648 | — | — |
| 2026-06-10 | YOUNG, WILLIAM D | Director | Buy | 1,371 | — | — |
| 2026-06-10 | NORDEN, GREGORY | Director | Buy | 648 | — | — |
| 2026-06-10 | NORDEN, GREGORY | Director | Buy | 1,371 | — | — |
| 2026-06-10 | MITCHELL, DEAN J | Director | Buy | 648 | — | — |
| 2026-06-10 | MITCHELL, DEAN J | Director | Buy | 1,371 | — | — |
| 2026-06-10 | KINDLER, JEFFREY B | Director | Buy | 648 | — | — |
| 2026-06-10 | KINDLER, JEFFREY B | Director | Buy | 1,371 | — | — |
| 2026-06-10 | DESIMONE, JILL | Director | Buy | 648 | — | — |
| 2026-06-10 | DESIMONE, JILL | Director | Buy | 1,371 | — | — |
| 2026-06-10 | CUDKOWICZ, MERIT ESTER | Director | Buy | 648 | — | — |
| 2026-06-10 | CUDKOWICZ, MERIT ESTER | Director | Buy | 1,371 | — | — |
| 2026-06-10 | CHODAKEWITZ, JEFFREY | Director | Buy | 648 | — | — |
| 2026-06-10 | CHODAKEWITZ, JEFFREY | Director | Buy | 1,371 | — | — |
| 2026-06-10 | ARBUCKLE, STUART A | Director | Buy | 648 | — | — |
| 2026-06-10 | ARBUCKLE, STUART A | Director | Buy | 1,371 | — | — |
| 2026-05-14 | SOUZA, MARCIO | Director, Chief Executive Officer | Buy | 126 | $167.94 | $21160.82 |
| 2026-05-14 | SNIECINSKI, MEGAN | Chief Operating Officer | Buy | 89 | $167.94 | $14946.93 |
| 2026-05-14 | NEMIROFF, ALEX | General Counsel and Secretary | Buy | 78 | $167.94 | $13099.55 |
| 2026-05-14 | MASTROCOLA, LAUREN | Principal Accounting Officer | Buy | 127 | $167.94 | $21328.76 |
| 2026-05-14 | KELLY, TIMOTHY EDWIN | Chief Financial Officer | Buy | 121 | $167.94 | $20321.10 |
| 2026-02-06 | KINDLER, JEFFREY B | Director | Buy | 224 | — | — |
| 2026-02-06 | KINDLER, JEFFREY B | Director | Buy | 688 | — | — |
| 2026-02-06 | KINDLER, JEFFREY B | Director | Buy | 478 | — | — |
| 2026-02-06 | ARBUCKLE, STUART A | Director | Buy | 224 | — | — |
| 2026-02-06 | ARBUCKLE, STUART A | Director | Buy | 688 | — | — |
| 2026-02-06 | ARBUCKLE, STUART A | Director | Buy | 478 | — | — |
| 2026-01-12 | SNIECINSKI, MEGAN | Chief Operating Officer | Sale | 885 | $275.74 | $244029.90 |
| 2026-01-12 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 768 | $275.74 | $211768.32 |
| 2026-01-12 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 344 | $275.74 | $94854.56 |
| 2026-01-12 | KELLY, TIMOTHY EDWIN | Chief Financial Officer | Sale | 943 | $275.74 | $260022.82 |
| 2026-01-10 | SOUZA, MARCIO | Director, Chief Executive Officer | Sale | 4,252 | $288.45 | $1.23M |
| 2026-01-10 | SNIECINSKI, MEGAN | Chief Operating Officer | Sale | 1,087 | $288.45 | $313545.15 |
| 2026-01-10 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 917 | $288.45 | $264508.65 |
| 2026-01-10 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 367 | $288.45 | $105861.15 |
| 2026-01-10 | KELLY, TIMOTHY EDWIN | Chief Financial Officer | Sale | 1,335 | $288.45 | $385080.75 |
| 2026-01-08 | SOUZA, MARCIO | Director, Chief Executive Officer | Buy | 22,110 | — | — |
| 2026-01-08 | SOUZA, MARCIO | Director, Chief Executive Officer | Buy | 27,640 | — | — |
| 2026-01-08 | SNIECINSKI, MEGAN | Chief Operating Officer | Buy | 7,700 | — | — |
| 2026-01-08 | SNIECINSKI, MEGAN | Chief Operating Officer | Buy | 9,625 | — | — |
| 2026-01-08 | NEMIROFF, ALEX | General Counsel and Secretary | Buy | 5,500 | — | — |
| 2026-01-08 | NEMIROFF, ALEX | General Counsel and Secretary | Buy | 6,875 | — | — |
| 2026-01-08 | MASTROCOLA, LAUREN | Principal Accounting Officer | Buy | 7,500 | — | — |
| 2026-01-08 | MASTROCOLA, LAUREN | Principal Accounting Officer | Buy | 3,750 | — | — |
| 2026-01-08 | KELLY, TIMOTHY EDWIN | Chief Financial Officer | Buy | 7,040 | — | — |
| 2026-01-08 | KELLY, TIMOTHY EDWIN | Chief Financial Officer | Buy | 8,800 | — | — |
| 2026-01-07 | SOUZA, MARCIO | Director, Chief Executive Officer | Sale | 405 | $292.63 | $118515.15 |
| 2026-01-07 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 89 | $292.63 | $26044.07 |
| 2026-01-07 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 35 | $292.63 | $10242.05 |
| 2026-01-07 | KELLY, TIMOTHY EDWIN | Chief Financial Officer | Sale | 139 | $292.63 | $40675.57 |
| 2025-12-30 | SOUZA, MARCIO | Director, Chief Executive Officer | Sale | 400 | — | — |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 9,100 | — | — |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 6,230 | — | — |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 5,652 | — | — |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 2,434 | — | — |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 1,714 | — | — |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 13,339 | $192.53 | $2.57M |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Buy | 9,100 | $56.94 | $518154.00 |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Buy | 6,230 | $133.65 | $832639.50 |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Buy | 5,652 | $44.40 | $250948.80 |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Buy | 2,434 | $44.40 | $108069.60 |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 1,714 | $190.86 | $327139.18 |
| 2025-11-20 | NEMIROFF, ALEX | General Counsel and Secretary | Sale | 977 | $193.23 | $188788.64 |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 5,250 | — | — |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 2,680 | — | — |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 2,351 | — | — |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 1,557 | — | — |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 1,047 | — | — |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 508 | — | — |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 207 | — | — |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 11,455 | $191.96 | $2.20M |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Buy | 5,250 | $56.94 | $298935.00 |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Buy | 2,680 | $43.37 | $116231.60 |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Buy | 2,351 | $44.40 | $104384.40 |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Sale | 2,145 | $192.71 | $413365.10 |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Buy | 1,557 | $133.65 | $208093.05 |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Buy | 1,047 | $49.50 | $51826.50 |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Buy | 508 | $83.85 | $42595.80 |
| 2025-11-20 | MASTROCOLA, LAUREN | Principal Accounting Officer | Buy | 207 | $44.40 | $9190.80 |
| 2025-11-14 | KELLY, TIMOTHY EDWIN | Chief Financial Officer | Buy | 384 | $31.62 | $12142.08 |
| 2025-10-16 | ADAGE, CAPITAL MANAGEMENT, L.P. | 10% Owner | Buy | 12,600 | $90.00 | $1.13M |
| 2025-10-16 | ADAGE, CAPITAL MANAGEMENT, L.P. | 10% Owner | Buy | 250,000 | $104.31 | $26.08M |
Frequently asked questions
Are PRAX insiders buying or selling?
Over the transactions on record, PRAX insiders have been net buyers, with about $12.61M in stock sold across 47 sales, against 21 open-market purchases.
Does insider selling at PRAX mean the stock will fall?
Not by itself. Most executive selling is pre-scheduled through 10b5-1 plans filed months in advance, and insiders sell for diversification, taxes, and liquidity far more often than out of any view on the price. Insider buying is the stronger signal, especially when several insiders buy around the same time, because there is usually only one reason to put personal cash into the stock.
Which PRAX insiders are selling the most?
Recent selling is concentrated in a few names. DESIMONE, JILL accounts for the largest share on record, with about $3.61M sold. Selling by one or two individuals matters less than broad selling across the whole leadership team, which is the pattern worth watching.