Puma Biotechnology Inc
NASDAQ: PBYI · HEALTHCARE · BIOTECHNOLOGY
Updated 2026-04-29
Puma Biotechnology Inc (PBYI) Stock Valuation Analysis
Fair value estimate, historical valuation range, and quality signals for PBYI.
Valued
Valuation reasonably reflects current fundamentals. Limited margin of safety at these levels.
PBYI historical valuation range
Where current P/E sits in PBYI's own 5Y range.
PBYI intrinsic value (DCF)
DCF-based fair value estimate vs current market price.
Intrinsic value calculated using discounted cash flow (DCF) model based on projected free cash flows, discount rate, and terminal growth assumptions. A positive margin of safety indicates the current price is below estimated fair value, providing a cushion against estimation error.
PBYI valuation signals
Quick-read green flags, caution flags, and risks based on current metrics.
P/E Ratio — History
Current: 12.31x
P/S Ratio — History
Current: 1.67x
Is PBYI overvalued in 2026?
Puma Biotechnology Inc (PBYI) currently trades at $7.48 per share with a market capitalization of $382,082,000.00. Based on our multi-factor framework, the stock trades at a fair valuation with a Smart Value Score of 71/100. This score blends growth quality, financial health, and price attractiveness into a single institutional-grade read.
The stock trades at a P/E ratio of 12.3x, above its 5-year median of 12.1x. The PEG ratio of 0.03 suggests earnings growth is outpacing the multiple, a classic sign of undervaluation.
Looking at its own history, PBYI is currently trading more expensive than 59% of the last 5Y on P/E. This places it in the 59th percentile of its historical range, a reasonable but unremarkable position.
Our discounted cash flow model estimates PBYI's intrinsic value at $28.43 per share, against the current market price of $7.48. This implies a margin of safety of +76.64%. A meaningful cushion exists against model error, making this a reasonable risk-adjusted entry.
Financial quality is a concern. The Piotroski F-Score of 0/9 flags weakening fundamentals that deserve closer scrutiny before the valuation case can be fully trusted.
Bottom line: PBYI trades at a fair valuation on our framework, with a Smart Value Score of 71/100. The valuation is defensible but offers no obvious bargain. Patience or a better entry price may reward disciplined buyers.
Frequently asked questions
Is PBYI overvalued in 2026?
Based on a Smart Value Score of 71/100, PBYI is fairly valued. Price reasonably reflects current fundamentals with limited cushion in either direction.
What is PBYI's fair value?
Our DCF model estimates PBYI's intrinsic value at $28.43 per share, versus the current price of $7.48. This produces a margin of safety of +76.64%.
What P/E ratio does PBYI trade at?
PBYI trades at a P/E of 12.3x on trailing twelve-month earnings, compared to its 5-year median of 12.1x.
Is PBYI a buy based on valuation?
WallStSmart does not issue buy or sell recommendations. Our Smart Value Score of 71/100 reflects the combined read on growth, quality, and price. The profile is balanced. Best suited for investors with an existing thesis.
How does PBYI's valuation compare to its history?
On P/E, PBYI currently sits in the 59th percentile of its own 5Y range. That is above its long-run median relative to where it has traded over the period.
What is PBYI's Smart Value Score?
PBYI's Smart Value Score is 71/100. The Smart Value Score is a proprietary WallStSmart metric blending growth quality, financial health, and valuation attractiveness into a single 0-100 read. Scores above 75 are rare and indicate strong multi-factor alignment.