OPK
Opko Health Inc
NASDAQ: OPK · HEALTHCARE · DIAGNOSTICS & RESEARCH
$1.12
-1.37% today
Updated 2026-06-05
Market cap
$1.06B
P/E ratio
—
P/S ratio
1.82x
EPS (TTM)
$-0.27
Dividend yield
—
52W range
$1 – $2
Volume
2.5M
Opko Health Inc (OPK) Insider transactions
Net insider activity
Net buying (15,821,592 shares)
Buy transactions
80
Sell transactions
20
All transactions
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-03-20 | PAGANELLI, JOHN A | Director | Buy | 10,000 | $1.14 | $11350.00 |
| 2026-03-18 | UPPALURI, SUBBARAO V | Director | Buy | 50,000 | — | — |
| 2025-11-21 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 192,870 | $1.34 | $257481.45 |
| 2025-11-21 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 191,490 | $1.33 | $254681.70 |
| 2025-11-21 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 102,371 | $1.30 | $133082.30 |
| 2025-11-21 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 89,375 | $1.33 | $118421.88 |
| 2025-11-21 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 3,894 | $1.32 | $5140.08 |
| 2025-11-20 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 211,948 | $1.33 | $281890.84 |
| 2025-11-20 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 161,818 | $1.34 | $216027.03 |
| 2025-11-20 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 119,129 | $1.32 | $157250.28 |
| 2025-11-20 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 47,105 | $1.33 | $62414.13 |
| 2025-11-20 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 24,579 | $1.34 | $32935.86 |
| 2025-11-20 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 13,664 | $1.35 | $18446.40 |
| 2025-11-20 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 1,757 | $1.35 | $2363.16 |
| 2025-11-19 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 198,904 | $1.32 | $261558.76 |
| 2025-11-19 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 155,496 | $1.32 | $205254.72 |
| 2025-11-19 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 66,504 | $1.31 | $87120.24 |
| 2025-11-19 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 58,160 | $1.29 | $74735.60 |
| 2025-11-19 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 36,325 | $1.28 | $46496.00 |
| 2025-11-19 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 30,082 | $1.30 | $39106.60 |
| 2025-11-19 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 21,236 | $1.30 | $27500.62 |
| 2025-11-19 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 12,993 | $1.31 | $16955.86 |
| 2025-11-19 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 300 | $1.29 | $387.00 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 212,608 | $1.28 | $271075.20 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 83,556 | $1.29 | $107369.46 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 69,728 | $1.28 | $89251.84 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 66,635 | $1.26 | $83626.92 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 49,590 | $1.25 | $61987.50 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 46,700 | $1.26 | $58842.00 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 33,572 | $1.29 | $43307.88 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 15,000 | $1.27 | $18975.00 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 1,772 | $1.27 | $2250.44 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 428 | $1.28 | $549.85 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 410 | $1.25 | $510.45 |
| 2025-11-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 1 | $1.29 | $1.29 |
| 2025-10-31 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 150,000 | $1.42 | $213435.00 |
| 2025-08-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Sale | 440,000 | — | — |
| 2025-08-08 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 675,000 | $1.32 | $891000.00 |
| 2025-05-27 | ZERHOUNI, ELIAS A. | Director, Vice Chairman and President | Buy | 500,000 | — | — |
| 2025-05-27 | RUBIN, STEVEN D | Director, Executive VP-Administration | Buy | 437,500 | — | — |
| 2025-05-27 | NABEL, GARY J. | Director, Chief Innovation Officer | Buy | 437,500 | — | — |
| 2025-05-27 | LOGAL, ADAM | Sr. Vice President, CFO | Buy | 437,500 | — | — |
| 2025-05-27 | HSIAO, JANE PH D | Director, Vice Chairman & CTO | Buy | 500,000 | — | — |
| 2025-05-27 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 500,000 | — | — |
| 2025-04-23 | YU, ALICE LIN-TSING | Director | Buy | 30,000 | — | — |
| 2025-04-23 | PFENNIGER, RICHARD C JR | Director | Buy | 60,000 | — | — |
| 2025-04-23 | PAGANELLI, JOHN A | Director | Buy | 30,000 | — | — |
| 2025-04-23 | MEDEL, ROGER MD | Director | Buy | 30,000 | — | — |
| 2025-04-23 | LACHMAN, PREM A | Director | Buy | 30,000 | — | — |
| 2025-04-23 | KRASNO, RICHARD M | Director | Buy | 30,000 | — | — |
| 2025-04-10 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 125,000 | $1.36 | $169712.50 |
| 2025-04-08 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 125,000 | $1.48 | $184650.00 |
| 2025-04-01 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 100,000 | $1.65 | $164850.00 |
| 2025-03-28 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 150,000 | $1.70 | $254385.00 |
| 2025-03-17 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 200,000 | $1.74 | $347820.00 |
| 2025-02-28 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 67,434 | $1.71 | $115312.14 |
| 2025-01-28 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 47,537 | $1.47 | $70060.03 |
| 2025-01-17 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 150,000 | $1.47 | $220425.00 |
| 2025-01-15 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 500,000 | $1.48 | $740850.00 |
| 2024-12-13 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 125,000 | $1.60 | $199375.00 |
| 2024-12-11 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 500,000 | $1.56 | $781050.00 |
| 2024-11-29 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 199,072 | $1.53 | $305376.45 |
| 2024-11-22 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 100,000 | $1.59 | $159000.00 |
| 2024-11-14 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 100,000 | $1.62 | $161980.00 |
| 2024-11-08 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 280,183 | $1.50 | $421535.32 |
| 2024-08-19 | OPKO, HEALTH, INC. | 10% Owner | Sale | 50,000 | $34.49 | $1.72M |
| 2024-08-16 | OPKO, HEALTH, INC. | 10% Owner | Sale | 50,000 | $34.30 | $1.71M |
| 2024-08-15 | OPKO, HEALTH, INC. | 10% Owner | Sale | 39,824 | $33.08 | $1.32M |
| 2024-08-13 | OPKO, HEALTH, INC. | 10% Owner | Sale | 24,987 | $34.76 | $868503.14 |
| 2024-08-12 | OPKO, HEALTH, INC. | 10% Owner | Sale | 59,787 | $33.95 | $2.03M |
| 2024-08-08 | OPKO, HEALTH, INC. | 10% Owner | Sale | 100,000 | $31.82 | $3.18M |
| 2024-08-06 | OPKO, HEALTH, INC. | 10% Owner | Sale | 12,994 | $29.35 | $381427.18 |
| 2024-07-31 | OPKO, HEALTH, INC. | 10% Owner | Sale | 88,839 | $33.50 | $2.98M |
| 2024-07-29 | OPKO, HEALTH, INC. | 10% Owner | Sale | 50,000 | $33.86 | $1.69M |
| 2024-07-26 | OPKO, HEALTH, INC. | 10% Owner | Sale | 60,000 | $33.85 | $2.03M |
| 2024-07-24 | ZERHOUNI, ELIAS A. | Director, Vice Chairman and President | Buy | 500,000 | — | — |
| 2024-07-24 | RUBIN, STEVEN D | Director, Executive VP-Administration | Buy | 437,500 | — | — |
| 2024-07-24 | OPKO, HEALTH, INC. | 10% Owner | Sale | 75,000 | $33.72 | $2.53M |
| 2024-07-24 | NABEL, GARY J. | Director, Chief Innovation Officer | Buy | 437,500 | — | — |
| 2024-07-24 | LOGAL, ADAM | Sr. Vice President, CFO | Buy | 437,500 | — | — |
| 2024-07-24 | HSIAO, JANE PH D | Director, Vice Chairman & CTO | Buy | 500,000 | — | — |
| 2024-07-24 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 500,000 | — | — |
| 2024-07-23 | OPKO, HEALTH, INC. | 10% Owner | Sale | 75,000 | $33.46 | $2.51M |
| 2024-07-22 | OPKO, HEALTH, INC. | 10% Owner | Sale | 50,000 | $32.61 | $1.63M |
| 2024-07-19 | OPKO, HEALTH, INC. | 10% Owner | Sale | 25,000 | $32.29 | $807250.00 |
| 2024-07-17 | OPKO, HEALTH, INC. | 10% Owner | Sale | 25,000 | $32.93 | $823187.50 |
| 2024-07-05 | OPKO, HEALTH, INC. | 10% Owner | Sale | 36,118 | $28.24 | $1.02M |
| 2024-07-03 | OPKO, HEALTH, INC. | 10% Owner | Sale | 14,082 | $28.23 | $397491.21 |
| 2024-07-02 | OPKO, HEALTH, INC. | 10% Owner | Sale | 25,000 | $29.12 | $728095.00 |
| 2024-07-01 | OPKO, HEALTH, INC. | 10% Owner | Sale | 50,000 | $26.63 | $1.33M |
| 2024-05-23 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 99,230 | $1.27 | $125962.56 |
| 2024-05-23 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 770 | $1.27 | $974.05 |
| 2024-05-17 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 163,997 | $1.29 | $211195.34 |
| 2024-03-18 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 500,000 | $0.87 | $437100.00 |
| 2024-03-14 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 500,000 | $0.89 | $444300.00 |
| 2024-03-13 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 500,000 | $0.93 | $463750.00 |
| 2024-03-12 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 600,000 | $0.93 | $559380.00 |
| 2024-02-28 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 500,000 | $0.99 | $496150.00 |
| 2024-02-21 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 1,000,000 | $0.99 | $991700.00 |
| 2024-02-07 | FROST, PHILLIP MD ET AL | Director, CEO & Chairman, 10% Owner | Buy | 1,500,000 | $0.98 | $1.46M |
Frequently asked questions
Are OPK insiders buying or selling?
Over the transactions on record, OPK insiders have been net buyers, with about $29.70M in stock sold across 20 sales, against 61 open-market purchases.
Does insider selling at OPK mean the stock will fall?
Not by itself. Most executive selling is pre-scheduled through 10b5-1 plans filed months in advance, and insiders sell for diversification, taxes, and liquidity far more often than out of any view on the price. Insider buying is the stronger signal, especially when several insiders buy around the same time, because there is usually only one reason to put personal cash into the stock.
Which OPK insiders are selling the most?
Recent selling is concentrated in a few names. OPKO, HEALTH, INC. accounts for the largest share on record, with about $29.70M sold. Selling by one or two individuals matters less than broad selling across the whole leadership team, which is the pattern worth watching.