Orchestra BioMed Holdings Inc.
NASDAQ: OBIO · HEALTHCARE · BIOTECHNOLOGY
Updated 2026-06-05
Orchestra BioMed Holdings Inc. (OBIO) Stock Valuation Analysis
Fair value estimate, historical valuation range, and quality signals for OBIO.
Current price exceeds what fundamentals support. Risk/reward skewed unfavorably.
OBIO historical valuation range
Where current P/E sits in OBIO's own 5Y range.
OBIO intrinsic value (DCF)
DCF-based fair value estimate vs current market price.
Standard discounted cash flow models produce unreliable output for unprofitable or near-breakeven companies. Revenue-based multiples such as P/S and EV/Sales, combined with the historical valuation position above, give a more reliable read for this stock.
Intrinsic value calculated using discounted cash flow (DCF) model based on projected free cash flows, discount rate, and terminal growth assumptions. A positive margin of safety indicates the current price is below estimated fair value, providing a cushion against estimation error.
OBIO valuation signals
Quick-read green flags, caution flags, and risks based on current metrics.
P/E Ratio — History
P/S Ratio — History
Current: 7.37x
Is OBIO overvalued in 2026?
Orchestra BioMed Holdings Inc. (OBIO) currently trades at $4.06 per share with a market capitalization of $241,319,000.00. Based on our multi-factor framework, the stock appears richly valued with a Smart Value Score of 16/100. This score blends growth quality, financial health, and price attractiveness into a single institutional-grade read.
OBIO currently has no meaningful P/E ratio, which typically signals that the company is unprofitable, near breakeven, or emerging from a loss-making period. With a P/S ratio of 7.4x, the market is valuing the company primarily on its revenue rather than its earnings.
A standard DCF model does not produce reliable output for OBIO under current conditions. For unprofitable or near-breakeven companies, revenue-based multiples such as EV/Sales and historical P/S percentile are more informative than intrinsic value calculations.
The Piotroski F-Score of 6/9 puts financial quality in a middling range, neither a standout strength nor an obvious red flag.
Bottom line: OBIO appears richly valued on our framework, with a Smart Value Score of 16/100. At current levels the risk/reward is skewed against the buyer. A materially lower price or significant operational improvement would be needed to change the picture.
Frequently asked questions
Is OBIO overvalued?
OBIO scores 16/100 on our Smart Value Score (Grade F), a weak overall profile. A standard DCF is unreliable here given the profitability profile, so valuation leans on revenue-based measures like EV/Sales and the P/S percentile below.
What is OBIO's fair value?
A standard DCF is unreliable for OBIO given its current profitability profile. Revenue-based approaches like EV/Sales or the historical P/S percentile are more informative for this stock.
What P/E ratio does OBIO trade at?
OBIO does not have a meaningful P/E right now, usually a sign of unprofitability or an earnings transition. For unprofitable growth names, price-to-sales is the more useful gauge.
Is OBIO a buy based on valuation?
Our Smart Value rating for OBIO is Strong Sell, from a Smart Value Score of 16/100 that blends growth, quality, and valuation. The profile skews cautious, and a better price or clearer operating improvement would strengthen the case. This is research to inform your decision, not personalized financial advice.
How does OBIO's valuation compare to its history?
There is not enough historical valuation data yet for a confident percentile read on OBIO.
What is OBIO's Smart Value Score?
OBIO's Smart Value Score is 16/100. It is a proprietary WallStSmart metric blending growth quality, financial health, and valuation into a single 0-100 read, and scores above 75 are rare, signaling strong multi-factor alignment.