Nautilus Biotechnology Inc
NASDAQ: NAUT · HEALTHCARE · BIOTECHNOLOGY
Updated 2026-04-29
Nautilus Biotechnology Inc (NAUT) Stock Valuation Analysis
Fair value estimate, historical valuation range, and quality signals for NAUT.
Current price exceeds what fundamentals support. Risk/reward skewed unfavorably.
NAUT historical valuation range
Where current P/E sits in NAUT's own 5Y range.
NAUT intrinsic value (DCF)
DCF-based fair value estimate vs current market price.
Standard discounted cash flow models produce unreliable output for unprofitable or near-breakeven companies. Revenue-based multiples such as P/S and EV/Sales, combined with the historical valuation position above, give a more reliable read for this stock.
Intrinsic value calculated using discounted cash flow (DCF) model based on projected free cash flows, discount rate, and terminal growth assumptions. A positive margin of safety indicates the current price is below estimated fair value, providing a cushion against estimation error.
NAUT valuation signals
Quick-read green flags, caution flags, and risks based on current metrics.
P/E Ratio — History
P/S Ratio — History
Current: 0.00x
Is NAUT overvalued in 2026?
Nautilus Biotechnology Inc (NAUT) currently trades at $2.50 per share with a market capitalization of $317,697,000.00. Based on our multi-factor framework, the stock appears richly valued with a Smart Value Score of 25/100. This score blends growth quality, financial health, and price attractiveness into a single institutional-grade read.
NAUT currently has no meaningful P/E ratio, which typically signals that the company is unprofitable, near breakeven, or emerging from a loss-making period.
A standard DCF model does not produce reliable output for NAUT under current conditions. For unprofitable or near-breakeven companies, revenue-based multiples such as EV/Sales and historical P/S percentile are more informative than intrinsic value calculations.
Financial quality is a concern. The Piotroski F-Score of 1/9 flags weakening fundamentals that deserve closer scrutiny before the valuation case can be fully trusted.
Bottom line: NAUT appears richly valued on our framework, with a Smart Value Score of 25/100. At current levels the risk/reward is skewed against the buyer. A materially lower price or significant operational improvement would be needed to change the picture.
Frequently asked questions
Is NAUT overvalued in 2026?
Based on a Smart Value Score of 25/100, NAUT appears overvalued. Current price exceeds what fundamentals currently justify.
What is NAUT's fair value?
Standard DCF is unreliable for NAUT due to its current profitability profile. Revenue-based approaches such as EV/Sales or historical P/S percentile are more informative for this stock.
What P/E ratio does NAUT trade at?
NAUT does not have a meaningful P/E ratio at this time, typically a sign of unprofitability or an ongoing earnings transition.
Is NAUT a buy based on valuation?
WallStSmart does not issue buy or sell recommendations. Our Smart Value Score of 25/100 reflects the combined read on growth, quality, and price. The profile skews cautious. Consider waiting for a better price or clearer operational improvement.
How does NAUT's valuation compare to its history?
Insufficient historical valuation data exists yet for a confident percentile read on NAUT.
What is NAUT's Smart Value Score?
NAUT's Smart Value Score is 25/100. The Smart Value Score is a proprietary WallStSmart metric blending growth quality, financial health, and valuation attractiveness into a single 0-100 read. Scores above 75 are rare and indicate strong multi-factor alignment.