DSGN
Design Therapeutics Inc
NASDAQ: DSGN · HEALTHCARE · BIOTECHNOLOGY
$10.34
+1.87% today
Updated 2026-11-03
Market cap
$635.20M
P/E ratio
—
P/S ratio
29,402.82x
EPS (TTM)
$-1.18
Dividend yield
—
52W range
$6 – $17
Volume
0.6M
Design Therapeutics Inc (DSGN) Insider transactions
Net insider activity
Net buying (13,967,347 shares)
Buy transactions
85
Sell transactions
8
All transactions
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-06-09 | SHAPIRO, DAVID | Director | Buy | 30,000 | — | — |
| 2026-06-09 | SCHMID, JOHN P. | Director | Buy | 30,000 | — | — |
| 2026-06-09 | LAPPE, RODNEY W | Director | Buy | 30,000 | — | — |
| 2026-06-09 | GOVER, JUSTIN D. | Director | Buy | 30,000 | — | — |
| 2026-06-09 | GEORGE, SIMEON | Director, 10% Owner | Buy | 30,000 | — | — |
| 2026-06-09 | BERGER, HEATHER A. | Director | Buy | 30,000 | — | — |
| 2026-03-31 | SHAPIRO, DAVID | Director | Buy | 60,000 | — | — |
| 2026-03-31 | SHAPIRO, DAVID | Director | Buy | 7,500 | — | — |
| 2026-01-02 | STORGARD, CHRIS | Chief Medical Officer | Buy | 250,000 | — | — |
| 2026-01-02 | SHAH, PRATIK | Director, President, CEO and Chairperson | Buy | 750,000 | — | — |
| 2026-01-02 | JEFFRIES, SEAN | Chief Operating Officer | Buy | 375,000 | — | — |
| 2026-01-02 | GOVER, JUSTIN D. | Director | Buy | 45,000 | — | — |
| 2026-01-02 | BURGESS, JULIE | Chief Accounting Officer | Buy | 150,000 | — | — |
| 2025-12-09 | SHAH, PRATIK | Director, President, CEO and Chairperson | Buy | 525,000 | — | — |
| 2025-09-09 | GOVER, JUSTIN D. | Director | Buy | 30,000 | — | — |
| 2025-09-09 | GOVER, JUSTIN D. | Director | Buy | 15,833 | — | — |
| 2025-08-13 | WILLIAM, ARSANI | Director | Sale | 345,000 | $5.25 | $1.81M |
| 2025-08-13 | WILLIAM, ARSANI | Director | Sale | 217,627 | $5.25 | $1.14M |
| 2025-06-10 | WILLIAM, ARSANI | Director | Buy | 19,000 | — | — |
| 2025-06-10 | SCHMID, JOHN P. | Director | Buy | 19,000 | — | — |
| 2025-06-10 | PRASAD, DEEPA | Director | Buy | 19,000 | — | — |
| 2025-06-10 | LAPPE, RODNEY W | Director | Buy | 19,000 | — | — |
| 2025-06-10 | GEORGE, SIMEON | Director, 10% Owner | Buy | 19,000 | — | — |
| 2025-06-10 | BERGER, HEATHER A. | Director | Buy | 19,000 | — | — |
| 2025-05-01 | STORGARD, CHRIS | Chief Medical Officer | Buy | 400,000 | — | — |
| 2025-01-02 | SHAH, PRATIK | Director, President, CEO and Chairperson | Buy | 600,000 | — | — |
| 2025-01-02 | LAPPE, RODNEY W | Director | Buy | 25,993 | — | — |
| 2025-01-02 | JEFFRIES, SEAN | Chief Operating Officer | Buy | 260,000 | — | — |
| 2025-01-02 | BURGESS, JULIE | Chief Accounting Officer | Buy | 135,000 | — | — |
| 2024-12-18 | PRASAD, DEEPA | Director | Sale | 3,806 | $6.27 | $23863.62 |
| 2024-08-09 | WILLIAM, ARSANI | Director | Sale | 814,874 | $4.25 | $3.46M |
| 2024-06-13 | WILLIAM, ARSANI | Director | Buy | 19,000 | — | — |
| 2024-06-13 | SCHMID, JOHN P. | Director | Buy | 19,000 | — | — |
| 2024-06-13 | PRASAD, DEEPA | Director | Buy | 19,000 | — | — |
| 2024-06-13 | LAPPE, RODNEY W | Director | Buy | 19,000 | — | — |
| 2024-06-13 | GEORGE, SIMEON | Director, 10% Owner | Buy | 19,000 | — | — |
| 2024-06-13 | BERGER, HEATHER A. | Director | Buy | 19,000 | — | — |
| 2024-03-25 | SCHMID, JOHN P. | Director | Buy | 17,809 | $3.74 | $66605.66 |
| 2024-03-25 | BERGER, HEATHER A. | Director | Buy | 1,300 | $3.74 | $4865.77 |
| 2024-03-22 | SCHMID, JOHN P. | Director | Buy | 9,156 | $3.62 | $33132.82 |
| 2024-01-02 | JEFFRIES, SEAN | Chief Operating Officer | Buy | 350,000 | — | — |
| 2024-01-02 | BURGESS, JULIE | Chief Accounting Officer | Buy | 110,000 | — | — |
| 2023-12-01 | LAPPE, RODNEY W | Director | Buy | 69,186 | — | — |
| 2023-12-01 | ANSARI, ASEEM Z. | 10% Owner | Buy | 100,000 | — | — |
| 2023-09-29 | LAPPE, RODNEY W | Director | Buy | 21,000 | $2.35 | $49287.00 |
| 2023-09-01 | SHAH, PRATIK | Director, President, CEO and Chairperson | Buy | 1,050,000 | — | — |
| 2023-09-01 | SHAH, PRATIK | Director, President, CEO and Chairperson | Buy | 525,000 | — | — |
| 2023-08-29 | WILLIAM, ARSANI | Director | Buy | 1,960,000 | $2.44 | $4.78M |
| 2023-08-29 | PRASAD, DEEPA | Director | Buy | 12,000 | $2.31 | $27669.60 |
| 2023-08-28 | WILLIAM, ARSANI | Director | Buy | 275,000 | $2.15 | $591250.00 |
| 2023-05-31 | XU, STELLA | Director | Buy | 15,000 | — | — |
| 2023-05-31 | WILLIAM, ARSANI | Director | Buy | 15,000 | — | — |
| 2023-05-31 | SCHMID, JOHN P. | Director | Buy | 15,000 | — | — |
| 2023-05-31 | PRASAD, DEEPA | Director | Buy | 15,000 | — | — |
| 2023-05-31 | LAPPE, RODNEY W | Director | Buy | 15,000 | — | — |
| 2023-05-31 | GEORGE, SIMEON | Director, 10% Owner | Buy | 15,000 | — | — |
| 2023-05-31 | BERGER, HEATHER A. | Director | Buy | 15,000 | — | — |
| 2023-02-01 | SIFFERT, JOAO MD | Director, President and CEO | Buy | 415,000 | — | — |
| 2023-02-01 | SHAH, PRATIK | Director, Executive Chairperson | Buy | 415,000 | — | — |
| 2023-02-01 | JEFFRIES, SEAN | Chief Operating Officer | Buy | 140,000 | — | — |
| 2023-02-01 | BURGESS, JULIE | Chief Accounting Officer | Buy | 75,000 | — | — |
| 2022-12-20 | SR, ONE CAPITAL FUND I AGGREGATOR LP | 10% Owner | Buy | 40,000 | $8.14 | $325432.00 |
| 2022-12-20 | SIFFERT, JOAO MD | Director, President and CEO | Buy | 6,300 | $8.38 | $52762.50 |
| 2022-12-20 | GEORGE, SIMEON | Director, 10% Owner | Buy | 40,000 | $8.14 | $325432.00 |
| 2022-12-19 | SR, ONE CAPITAL FUND I AGGREGATOR LP | 10% Owner | Buy | 360,000 | $8.63 | $3.11M |
| 2022-12-19 | SIFFERT, JOAO MD | Director, President and CEO | Buy | 1,150 | $8.47 | $9740.50 |
| 2022-12-19 | GEORGE, SIMEON | Director, 10% Owner | Buy | 360,000 | $8.63 | $3.11M |
| 2022-12-16 | SR, ONE CAPITAL FUND I AGGREGATOR LP | 10% Owner | Buy | 500,000 | $8.28 | $4.14M |
| 2022-12-16 | GEORGE, SIMEON | Director, 10% Owner | Buy | 500,000 | $8.28 | $4.14M |
| 2022-12-09 | LAPPE, RODNEY W | Director | Buy | 15,000 | $7.96 | $119425.50 |
| 2022-06-15 | XU, STELLA | Director | Buy | 15,000 | — | — |
| 2022-06-15 | WILLIAM, ARSANI | Director | Buy | 15,000 | — | — |
| 2022-06-15 | SCHMID, JOHN P. | Director | Buy | 15,000 | — | — |
| 2022-06-15 | PRASAD, DEEPA | Director | Buy | 15,000 | — | — |
| 2022-06-15 | LAPPE, RODNEY W | Director | Buy | 15,000 | — | — |
| 2022-06-15 | GEORGE, SIMEON | Director, 10% Owner | Buy | 15,000 | — | — |
| 2022-06-15 | BERGER, HEATHER A. | Director | Buy | 15,000 | — | — |
| 2022-03-22 | XU, STELLA | Director | Sale | 1,455 | $18.63 | $27105.49 |
| 2022-03-21 | XU, STELLA | Director | Sale | 24,000 | $19.01 | $456240.00 |
| 2022-03-21 | WILLIAM, ARSANI | Director | Buy | 25,000 | $18.99 | $474680.00 |
| 2022-03-18 | XU, STELLA | Director | Sale | 552,225 | $19.04 | $10.51M |
| 2022-03-18 | XU, STELLA | Director | Sale | 13,200 | $20.34 | $268488.00 |
| 2022-03-16 | PRASAD, DEEPA | Director | Buy | 11,806 | — | — |
| 2022-02-01 | SIFFERT, JOAO MD | Director, President and CEO | Buy | 475,000 | — | — |
| 2022-02-01 | SHAH, PRATIK | Director, Executive Chairperson | Buy | 475,000 | — | — |
| 2022-02-01 | JEFFRIES, SEAN | Chief Operating Officer | Buy | 350,000 | — | — |
| 2022-02-01 | BURGESS, JULIE | Chief Accounting Officer | Buy | 50,000 | — | — |
| 2021-10-01 | BURGESS, JULIE | Chief Accounting Officer | Buy | 135,000 | — | — |
| 2021-08-31 | WILLIAM, ARSANI | Director | Buy | 40,000 | $15.45 | $618000.00 |
| 2021-06-15 | PRASAD, DEEPA | Director | Buy | 30,000 | — | — |
| 2021-03-30 | WILLIAM, ARSANI | Director | Buy | 1,217,627 | — | — |
| 2021-03-30 | WILLIAM, ARSANI | Director | Buy | 814,874 | — | — |
| 2021-03-30 | WILLIAM, ARSANI | Director | Buy | 700,000 | $20.00 | $14.00M |
Frequently asked questions
Are DSGN insiders buying or selling?
Over the transactions on record, DSGN insiders have been net buyers, with about $17.71M in stock sold across 8 sales, against 19 open-market purchases.
Does insider selling at DSGN mean the stock will fall?
Not by itself. Most executive selling is pre-scheduled through 10b5-1 plans filed months in advance, and insiders sell for diversification, taxes, and liquidity far more often than out of any view on the price. Insider buying is the stronger signal, especially when several insiders buy around the same time, because there is usually only one reason to put personal cash into the stock.
Which DSGN insiders are selling the most?
Recent selling is concentrated in a few names. XU, STELLA accounts for the largest share on record, with about $11.27M sold. Selling by one or two individuals matters less than broad selling across the whole leadership team, which is the pattern worth watching.