ARWR
Arrowhead Pharmaceuticals Inc
NASDAQ: ARWR · HEALTHCARE · BIOTECHNOLOGY
$77.74
-2.75% today
Updated 2026-06-05
Market cap
$10.50B
P/E ratio
—
P/S ratio
16.88x
EPS (TTM)
$-2.27
Dividend yield
—
52W range
$14 – $82
Volume
1.7M
Arrowhead Pharmaceuticals Inc (ARWR) Insider transactions
Net insider activity
Net selling (313,724 shares)
Buy transactions
16
Sell transactions
84
All transactions
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-05-12 | LU, HONGBO | Director | Sale | 2,970 | $76.88 | $228333.60 |
| 2026-04-23 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 10,000 | $75.00 | $750000.00 |
| 2026-04-22 | APEL, DANIEL JOSEPH | Chief Financial Officer | Sale | 8,730 | $71.92 | $627861.60 |
| 2026-04-22 | APEL, DANIEL JOSEPH | Chief Financial Officer | Sale | 3,208 | $70.11 | $224912.88 |
| 2026-04-22 | APEL, DANIEL JOSEPH | Chief Financial Officer | Sale | 1,157 | $70.45 | $81510.65 |
| 2026-03-05 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 10,000 | $64.19 | $641900.00 |
| 2026-01-06 | O'BRIEN, PATRICK | COO | Buy | 75,000 | — | — |
| 2026-01-06 | O'BRIEN, PATRICK | COO | Sale | 540 | — | — |
| 2026-01-06 | O'BRIEN, PATRICK | COO | Sale | 440 | — | — |
| 2026-01-06 | HAMILTON, JAMES C | Chief Medical Officer | Buy | 75,000 | — | — |
| 2026-01-06 | APEL, DANIEL JOSEPH | Chief Financial Officer | Buy | 75,000 | — | — |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 13,451 | $62.96 | $846874.96 |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 11,842 | $63.84 | $755993.28 |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 6,164 | $62.23 | $383585.72 |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 5,873 | $62.91 | $369470.43 |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 4,368 | $61.20 | $267321.60 |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 2,700 | $64.44 | $173988.00 |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 2,336 | $64.04 | $149597.44 |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 900 | $66.01 | $59409.00 |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 600 | $61.12 | $36672.00 |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 313 | $68.00 | $21284.00 |
| 2026-01-05 | O'BRIEN, PATRICK | COO | Sale | 46 | $68.00 | $3128.00 |
| 2026-01-05 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 14,792 | $63.01 | $932043.92 |
| 2026-01-05 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 12,711 | $63.95 | $812868.45 |
| 2026-01-05 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 6,090 | $62.28 | $379285.20 |
| 2026-01-05 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 4,625 | $61.24 | $283235.00 |
| 2026-01-05 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 1,200 | $64.49 | $77388.00 |
| 2026-01-05 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 437 | $65.97 | $28828.89 |
| 2026-01-05 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 309 | $68.00 | $21012.00 |
| 2026-01-02 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 7,416 | $65.88 | $488566.08 |
| 2026-01-02 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 5,771 | $66.39 | $383136.69 |
| 2025-12-31 | O'BRIEN, PATRICK | COO | Sale | 560 | — | — |
| 2025-12-29 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 35,181 | — | — |
| 2025-12-29 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 16,545 | — | — |
| 2025-12-29 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Buy | 35,181 | $6.15 | $216363.15 |
| 2025-12-29 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 16,545 | $68.69 | $1.14M |
| 2025-12-26 | FERRARI, MAURO | Director | Sale | 7,530 | $70.00 | $527100.00 |
| 2025-12-22 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 10,012 | $68.33 | $684119.96 |
| 2025-12-22 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 2,574 | $68.85 | $177219.90 |
| 2025-12-19 | WADDILL, WILLIAM D. | Director | Sale | 5,451 | $68.01 | $370722.51 |
| 2025-12-19 | WADDILL, WILLIAM D. | Director | Sale | 2,416 | $66.66 | $161050.56 |
| 2025-12-19 | WADDILL, WILLIAM D. | Director | Sale | 500 | $68.53 | $34265.00 |
| 2025-12-19 | VAKIENER, VICTORIA | Director | Sale | 5,281 | $67.97 | $358949.57 |
| 2025-12-19 | VAKIENER, VICTORIA | Director | Sale | 2,799 | $66.63 | $186497.37 |
| 2025-12-19 | VAKIENER, VICTORIA | Director | Sale | 1,960 | $68.39 | $134044.40 |
| 2025-12-19 | OLUKOTUN, ADEOYE Y | Director | Sale | 6,083 | $68.04 | $413887.32 |
| 2025-12-19 | OLUKOTUN, ADEOYE Y | Director | Sale | 3,090 | $66.70 | $206103.00 |
| 2025-12-19 | OLUKOTUN, ADEOYE Y | Director | Sale | 827 | $68.48 | $56632.96 |
| 2025-12-19 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 8,147 | $68.01 | $554077.47 |
| 2025-12-19 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 3,979 | $66.67 | $265279.93 |
| 2025-12-19 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 1,319 | $68.48 | $90325.12 |
| 2025-12-17 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 46,287 | $63.55 | $2.94M |
| 2025-12-17 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 35,750 | $64.51 | $2.31M |
| 2025-12-17 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 1,981 | $66.30 | $131340.30 |
| 2025-12-17 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 982 | $65.53 | $64350.46 |
| 2025-12-16 | WADDILL, WILLIAM D. | Director | Buy | 7,819 | — | — |
| 2025-12-16 | VAKIENER, VICTORIA | Director | Buy | 7,819 | — | — |
| 2025-12-16 | PERRY, MICHAEL S | Director | Buy | 7,819 | — | — |
| 2025-12-16 | OLUKOTUN, ADEOYE Y | Director | Buy | 7,819 | — | — |
| 2025-12-16 | LU, HONGBO | Director | Buy | 7,819 | — | — |
| 2025-12-16 | INGRAM, DOUGLAS S | Director | Buy | 7,819 | — | — |
| 2025-12-16 | FERRARI, MAURO | Director | Buy | 7,819 | — | — |
| 2025-12-16 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 14,095 | $62.12 | $875581.40 |
| 2025-12-16 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 10,963 | $61.25 | $671483.75 |
| 2025-12-16 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 8,476 | $62.94 | $533479.44 |
| 2025-12-16 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 8,416 | $60.51 | $509252.16 |
| 2025-12-16 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 6,661 | $64.29 | $428235.69 |
| 2025-12-16 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 3,221 | $67.87 | $218609.27 |
| 2025-12-16 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 1,300 | $65.77 | $85501.00 |
| 2025-12-16 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 1,000 | $64.96 | $64960.00 |
| 2025-12-16 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 166 | $66.77 | $11083.82 |
| 2025-12-15 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 100,532 | $68.67 | $6.90M |
| 2025-12-15 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 21,321 | $69.28 | $1.48M |
| 2025-12-15 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 8,147 | $69.96 | $569964.12 |
| 2025-12-12 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Buy | 180,000 | — | — |
| 2025-12-05 | PERRY, MICHAEL S | Director | Sale | 16,250 | $61.03 | $991737.50 |
| 2025-11-28 | FERRARI, MAURO | Director | Sale | 8,750 | $56.39 | $493412.50 |
| 2025-10-01 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 20,000 | $35.00 | $700000.00 |
| 2025-09-12 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 15,000 | $30.00 | $450000.00 |
| 2025-09-02 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 15,000 | $25.00 | $375000.00 |
| 2025-08-15 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 9,389 | $20.00 | $187780.00 |
| 2025-08-13 | HAMILTON, JAMES C | Chief Medical Officer | Sale | 611 | $20.00 | $12220.00 |
| 2025-04-11 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 50,800 | $11.49 | $583692.00 |
| 2025-04-10 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 50,000 | $10.87 | $543500.00 |
| 2025-04-09 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 35,305 | $9.93 | $350578.65 |
| 2025-04-09 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 3,400 | $10.75 | $36550.00 |
| 2025-04-09 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 1,617 | $11.76 | $19015.92 |
| 2025-03-13 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Buy | 340,000 | — | — |
| 2025-03-13 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 51,425 | $15.07 | $774974.75 |
| 2025-03-04 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Buy | 133,333 | $7.75 | $1.03M |
| 2025-03-03 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 166,667 | — | — |
| 2025-03-03 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 133,333 | — | — |
| 2025-03-03 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Sale | 166,667 | $18.03 | $3.01M |
| 2025-02-07 | ANZALONE, CHRISTOPHER RICHARD | Director, Chief Executive Officer | Buy | 9,550 | $20.10 | $191955.00 |
| 2025-02-06 | INGRAM, DOUGLAS S | Director | Buy | 38,396 | $20.09 | $771375.64 |
| 2025-01-23 | OLUKOTUN, ADEOYE Y | Director | Sale | 959 | $21.00 | $20139.00 |
| 2025-01-07 | O'BRIEN, PATRICK | COO and General Counsel | Sale | 8,000 | $19.69 | $157520.00 |
| 2025-01-07 | MYSZKOWSKI, KENNETH ALLEN | Chief Financial Officer | Sale | 10,000 | $19.69 | $196900.00 |
| 2025-01-07 | MYSZKOWSKI, KENNETH ALLEN | Chief Financial Officer | Sale | 8,000 | $19.70 | $157600.00 |
| 2025-01-06 | O'BRIEN, PATRICK | COO and General Counsel | Sale | 19,658 | $19.69 | $387066.02 |
Frequently asked questions
Are ARWR insiders buying or selling?
Over the transactions on record, ARWR insiders have been net sellers, with about $41.62M in stock sold across 84 sales, against 4 open-market purchases.
Does insider selling at ARWR mean the stock will fall?
Not by itself. Most executive selling is pre-scheduled through 10b5-1 plans filed months in advance, and insiders sell for diversification, taxes, and liquidity far more often than out of any view on the price. Insider buying is the stronger signal, especially when several insiders buy around the same time, because there is usually only one reason to put personal cash into the stock.
Which ARWR insiders are selling the most?
Recent selling is concentrated in a few names. ANZALONE, CHRISTOPHER RICHARD accounts for the largest share on record, with about $26.88M sold. Selling by one or two individuals matters less than broad selling across the whole leadership team, which is the pattern worth watching.