WallStSmart

Vertex Pharmaceuticals Inc (VRTX)vsZevra Therapeutics Inc. (ZVRA)

VS

Smart Verdict

WallStSmart Research — data-driven comparison

Vertex Pharmaceuticals Inc generates 11172% more annual revenue ($12.00B vs $106.47M). ZVRA leads profitability with a 78.2% profit margin vs 32.9%. VRTX appears more attractively valued with a PEG of 2.19. VRTX earns a higher WallStSmart Score of 66/100 (B-).

VRTX

Strong Buy

66

out of 100

Grade: B-

Growth: 8.0Profit: 9.0Value: 10.0Quality: 8.0
Piotroski: 3/9Altman Z: 3.62

ZVRA

Buy

62

out of 100

Grade: C+

Growth: 6.0Profit: 8.0Value: 6.0Quality: 5.0
IV

Intrinsic Value Comparison

Multi-model valuation · Graham Formula

VRTXUndervalued (+36.5%)

Margin of Safety

+36.5%

Fair Value

$716.04

Current Price

$454.97

$261.07 discount

UndervaluedFair: $716.04Overvalued
ZVRAUndervalued (+7.6%)

Margin of Safety

+7.6%

Fair Value

$9.18

Current Price

$9.13

$0.05 discount

UndervaluedFair: $9.18Overvalued

Key Strengths & Concerns

Side-by-side fundamental analysis

Key Strengths

VRTX6 strengths · Avg: 9.5/10
Profit MarginProfitability
32.9%10/10

Keeps 33 of every $100 in revenue as profit

Operating MarginProfitability
39.6%10/10

Strong operational efficiency at 39.6%

Altman Z-ScoreHealth
3.6210/10

Safe zone — low bankruptcy risk

Market CapQuality
$113.95B9/10

Large-cap with strong market position

Return on EquityProfitability
22.5%9/10

Every $100 of equity generates 23 in profit

Debt/EquityHealth
0.219/10

Conservative balance sheet, low leverage

ZVRA4 strengths · Avg: 9.5/10
P/E RatioValuation
6.8x10/10

Attractively priced relative to earnings

Return on EquityProfitability
85.7%10/10

Every $100 of equity generates 86 in profit

Profit MarginProfitability
78.2%10/10

Keeps 78 of every $100 in revenue as profit

Operating MarginProfitability
27.3%8/10

Strong operational efficiency at 27.3%

Areas to Watch

VRTX3 concerns · Avg: 3.7/10
PEG RatioValuation
2.194/10

Expensive relative to growth rate

P/E RatioValuation
29.3x4/10

Moderate valuation

Piotroski F-ScoreQuality
3/93/10

Weak financial health signals

ZVRA4 concerns · Avg: 3.3/10
Revenue GrowthGrowth
1.8%4/10

1.8% revenue growth

EPS GrowthGrowth
0.0%4/10

0.0% earnings growth

Market CapQuality
$537.21M3/10

Smaller company, higher risk/reward

PEG RatioValuation
10.672/10

Expensive relative to growth rate

Comparative Analysis Report

WallStSmart Research

Bull Case : VRTX

The strongest argument for VRTX centers on Profit Margin, Operating Margin, Altman Z-Score. Profitability is solid with margins at 32.9% and operating margin at 39.6%.

Bull Case : ZVRA

The strongest argument for ZVRA centers on P/E Ratio, Return on Equity, Profit Margin. Profitability is solid with margins at 78.2% and operating margin at 27.3%.

Bear Case : VRTX

The primary concerns for VRTX are PEG Ratio, P/E Ratio, Piotroski F-Score.

Bear Case : ZVRA

The primary concerns for ZVRA are Revenue Growth, EPS Growth, Market Cap.

Key Dynamics to Monitor

VRTX profiles as a mature stock while ZVRA is a value play — different risk/reward profiles.

ZVRA carries more volatility with a beta of 0.94 — expect wider price swings.

VRTX is growing revenue faster at 9.5% — sustainability is the question.

VRTX generates stronger free cash flow (349M), providing more financial flexibility.

Bottom Line

VRTX scores higher overall (66/100 vs 62/100), backed by strong 32.9% margins. Both earn "Strong Buy" and "Buy" ratings respectively — the choice depends on your investment horizon and risk tolerance.

This analysis is generated from publicly available financial data. Not financial advice.

Vertex Pharmaceuticals Inc

HEALTHCARE · BIOTECHNOLOGY · USA

Vertex Pharmaceuticals, Inc. is an American biopharmaceutical company based in Boston, Massachusetts.

Zevra Therapeutics Inc.

HEALTHCARE · BIOTECHNOLOGY · USA

Zevra Therapeutics, Inc., a rare disease company melding science, discovers and develops various proprietary prodrugs to treat serious medical conditions in the United States. The company is headquartered in Celebration, Florida.

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