Heron Therapeuti (HRTX)vsVertex Pharmaceuticals Inc (VRTX)

HRTX

Heron Therapeuti

NASDAQ

$0.44

-11.60%

HEALTHCARE · Cap: $80.78M

VRTX

Vertex Pharmaceuticals Inc

NASDAQ

$528.04

+6.03%

HEALTHCARE · Cap: $124.70B

⚡

Smart Verdict

WallStSmart Research — data-driven comparison

Vertex Pharmaceuticals Inc generates 8007% more annual revenue ($12.22B vs $150.71M). VRTX leads profitability with a 35.5% profit margin vs -20.5%. VRTX earns a higher WallStSmart Score of 68/100 (B-).

HRTX

Avoid

out of 100

Grade: F

Growth: 4.7Profit: 2.0Value: 5.0Quality: 4.5

Piotroski: 4/9Altman Z: -9.57

VRTX

Strong Buy

out of 100

Grade: B-

Growth: 8.0Profit: 9.0Value: 6.7Quality: 8.5

Piotroski: 3/9Altman Z: 3.61

Intrinsic Value Comparison

Multi-model valuation · Graham Formula

Intrinsic value data unavailable for HRTX.

VRTXUndervalued (+44.2%)

Margin of Safety

+44.2%

Fair Value

$946.78

Current Price

$528.04

$418.74 discount

UndervaluedFair: $946.78Overvalued

Key Strengths & Concerns

Side-by-side fundamental analysis

Key Strengths

HRTX0 strengths · Avg: 0/10

No standout strengths identified

VRTX6 strengths · Avg: 9.7/10

Profit MarginProfitability

35.5%10/10

Keeps 36 of every $100 in revenue as profit

Operating MarginProfitability

38.1%10/10

Strong operational efficiency at 38.1%

EPS GrowthGrowth

61.4%10/10

Earnings expanding 61.4% YoY

Altman Z-ScoreHealth

3.6110/10

Safe zone — low bankruptcy risk

Market CapQuality

$124.70B9/10

Large-cap with strong market position

Return on EquityProfitability

22.4%9/10

Every $100 of equity generates 22 in profit

Areas to Watch

HRTX4 concerns · Avg: 3.3/10

Price/BookValuation

11.0x4/10

Trading at 11.0x book value

EPS GrowthGrowth

0.0%4/10

0.0% earnings growth

Market CapQuality

$80.78M3/10

Smaller company, higher risk/reward

Return on EquityProfitability

-338.6%2/10

ROE of -338.6% — below average capital efficiency

VRTX3 concerns · Avg: 3.7/10

PEG RatioValuation

1.824/10

Expensive relative to growth rate

P/E RatioValuation

29.2x4/10

Moderate valuation

Piotroski F-ScoreQuality

3/93/10

Weak financial health signals

Comparative Analysis Report

WallStSmart Research

Bull Case : HRTX

HRTX has a balanced fundamental profile.

Bull Case : VRTX

The strongest argument for VRTX centers on Profit Margin, Operating Margin, EPS Growth. Profitability is solid with margins at 35.5% and operating margin at 38.1%.

Bear Case : HRTX

The primary concerns for HRTX are Price/Book, EPS Growth, Market Cap. Debt-to-equity of 15.50 is elevated, increasing financial risk.

Bear Case : VRTX

The primary concerns for VRTX are PEG Ratio, P/E Ratio, Piotroski F-Score.

Key Dynamics to Monitor

HRTX profiles as a turnaround stock while VRTX is a mature play — different risk/reward profiles.

HRTX carries more volatility with a beta of 1.57 — expect wider price swings.

VRTX is growing revenue faster at 7.8% — sustainability is the question.

VRTX generates stronger free cash flow (1.3B), providing more financial flexibility.

Bottom Line

VRTX scores higher overall (68/100 vs 27/100), backed by strong 35.5% margins. Both earn "Strong Buy" and "Avoid" ratings respectively — the choice depends on your investment horizon and risk tolerance.

This analysis is generated from publicly available financial data. Not financial advice.

Heron Therapeuti

HEALTHCARE · BIOTECHNOLOGY · USA

Heron Therapeutics, Inc., a biotechnology company, is dedicated to developing treatments to address unmet medical needs. The company is headquartered in San Diego, California.

Vertex Pharmaceuticals Inc

HEALTHCARE · BIOTECHNOLOGY · USA

Vertex Pharmaceuticals, Inc. is an American biopharmaceutical company based in Boston, Massachusetts.

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