WallStSmart

Alnylam Pharmaceuticals Inc (ALNY)vsArcturus Therapeutics Holdings Inc (ARCT)

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Smart Verdict

WallStSmart Research — data-driven comparison

Alnylam Pharmaceuticals Inc generates 7736% more annual revenue ($4.29B vs $54.71M). ALNY leads profitability with a 12.6% profit margin vs -143.8%. ALNY earns a higher WallStSmart Score of 65/100 (B-).

ALNY

Strong Buy

65

out of 100

Grade: B-

Growth: 8.0Profit: 8.0Value: 7.3Quality: 5.5
Piotroski: 4/9Altman Z: -0.07

ARCT

Avoid

27

out of 100

Grade: F

Growth: 2.7Profit: 2.0Value: 6.7Quality: 6.5
Piotroski: 2/9Altman Z: -0.17
IV

Intrinsic Value Comparison

Multi-model valuation · Graham Formula

ALNYUndervalued (+86.4%)

Margin of Safety

+86.4%

Fair Value

$2372.19

Current Price

$303.05

$2069.14 discount

UndervaluedFair: $2372.19Overvalued
ARCTUndervalued (+78.2%)

Margin of Safety

+78.2%

Fair Value

$33.91

Current Price

$7.30

$26.61 discount

UndervaluedFair: $33.91Overvalued

Key Strengths & Concerns

Side-by-side fundamental analysis

Key Strengths

ALNY4 strengths · Avg: 9.5/10
PEG RatioValuation
0.4810/10

Growing faster than its price suggests

Return on EquityProfitability
53.7%10/10

Every $100 of equity generates 54 in profit

Revenue GrowthGrowth
96.4%10/10

Revenue surging 96.4% year-over-year

Operating MarginProfitability
23.0%8/10

Strong operational efficiency at 23.0%

ARCT2 strengths · Avg: 9.5/10
Price/BookValuation
1.1x10/10

Reasonable price relative to book value

Debt/EquityHealth
0.109/10

Conservative balance sheet, low leverage

Areas to Watch

ALNY4 concerns · Avg: 2.8/10
EPS GrowthGrowth
0.0%4/10

0.0% earnings growth

Debt/EquityHealth
1.183/10

Elevated debt levels

P/E RatioValuation
70.9x2/10

Premium valuation, high expectations priced in

Price/BookValuation
37.6x2/10

Trading at 37.6x book value

ARCT4 concerns · Avg: 3.0/10
EPS GrowthGrowth
0.0%4/10

0.0% earnings growth

Market CapQuality
$220.85M3/10

Smaller company, higher risk/reward

Piotroski F-ScoreQuality
2/93/10

Weak financial health signals

Return on EquityProfitability
-41.1%2/10

ROE of -41.1% — below average capital efficiency

Comparative Analysis Report

WallStSmart Research

Bull Case : ALNY

The strongest argument for ALNY centers on PEG Ratio, Return on Equity, Revenue Growth. Revenue growth of 96.4% demonstrates continued momentum. PEG of 0.48 suggests the stock is reasonably priced for its growth.

Bull Case : ARCT

The strongest argument for ARCT centers on Price/Book, Debt/Equity.

Bear Case : ALNY

The primary concerns for ALNY are EPS Growth, Debt/Equity, P/E Ratio. A P/E of 70.9x leaves little room for execution misses.

Bear Case : ARCT

The primary concerns for ARCT are EPS Growth, Market Cap, Piotroski F-Score.

Key Dynamics to Monitor

ALNY profiles as a growth stock while ARCT is a turnaround play — different risk/reward profiles.

ARCT carries more volatility with a beta of 2.42 — expect wider price swings.

ALNY is growing revenue faster at 96.4% — sustainability is the question.

ALNY generates stronger free cash flow (49M), providing more financial flexibility.

Bottom Line

ALNY scores higher overall (65/100 vs 27/100) and 96.4% revenue growth. ARCT offers better value entry with a 78.2% margin of safety. Both earn "Strong Buy" and "Avoid" ratings respectively — the choice depends on your investment horizon and risk tolerance.

This analysis is generated from publicly available financial data. Not financial advice.

Alnylam Pharmaceuticals Inc

HEALTHCARE · BIOTECHNOLOGY · USA

Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing and commercializing RNA interference (RNAi) therapies. The company is headquartered in Cambridge, Massachusetts.

Arcturus Therapeutics Holdings Inc

HEALTHCARE · BIOTECHNOLOGY · USA

Arcturus Therapeutics Holdings Inc., an RNA drug company, focuses on the treatment of liver and respiratory diseases. The company is headquartered in San Diego, California.

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