WallStSmart

Actuate Therapeutics, Inc. Common stock (ACTU)vsAlnylam Pharmaceuticals Inc (ALNY)

VS

Smart Verdict

WallStSmart Research — data-driven comparison

ALNY leads profitability with a 12.6% profit margin vs 0.0%. ALNY earns a higher WallStSmart Score of 65/100 (B-).

ACTU

Avoid

20

out of 100

Grade: F

Growth: 4.3Profit: 3.0Value: 5.0Quality: 6.3
Piotroski: 3/9

ALNY

Strong Buy

65

out of 100

Grade: B-

Growth: 8.0Profit: 8.0Value: 7.3Quality: 5.5
Piotroski: 4/9Altman Z: -0.07
IV

Intrinsic Value Comparison

Multi-model valuation · Graham Formula

Intrinsic value data unavailable for ACTU.

ALNYUndervalued (+86.4%)

Margin of Safety

+86.4%

Fair Value

$2372.19

Current Price

$303.05

$2069.14 discount

UndervaluedFair: $2372.19Overvalued

Key Strengths & Concerns

Side-by-side fundamental analysis

Key Strengths

ACTU1 strengths · Avg: 9.0/10
Debt/EquityHealth
0.119/10

Conservative balance sheet, low leverage

ALNY4 strengths · Avg: 9.5/10
PEG RatioValuation
0.4810/10

Growing faster than its price suggests

Return on EquityProfitability
53.7%10/10

Every $100 of equity generates 54 in profit

Revenue GrowthGrowth
96.4%10/10

Revenue surging 96.4% year-over-year

Operating MarginProfitability
23.0%8/10

Strong operational efficiency at 23.0%

Areas to Watch

ACTU4 concerns · Avg: 3.8/10
Price/BookValuation
11.7x4/10

Trading at 11.7x book value

Revenue GrowthGrowth
0.0%4/10

0.0% revenue growth

EPS GrowthGrowth
0.0%4/10

0.0% earnings growth

Market CapQuality
$47.61M3/10

Smaller company, higher risk/reward

ALNY4 concerns · Avg: 2.8/10
EPS GrowthGrowth
0.0%4/10

0.0% earnings growth

Debt/EquityHealth
1.183/10

Elevated debt levels

P/E RatioValuation
70.9x2/10

Premium valuation, high expectations priced in

Price/BookValuation
37.6x2/10

Trading at 37.6x book value

Comparative Analysis Report

WallStSmart Research

Bull Case : ACTU

The strongest argument for ACTU centers on Debt/Equity.

Bull Case : ALNY

The strongest argument for ALNY centers on PEG Ratio, Return on Equity, Revenue Growth. Revenue growth of 96.4% demonstrates continued momentum. PEG of 0.48 suggests the stock is reasonably priced for its growth.

Bear Case : ACTU

The primary concerns for ACTU are Price/Book, Revenue Growth, EPS Growth.

Bear Case : ALNY

The primary concerns for ALNY are EPS Growth, Debt/Equity, P/E Ratio. A P/E of 70.9x leaves little room for execution misses.

Key Dynamics to Monitor

ACTU profiles as a value stock while ALNY is a growth play — different risk/reward profiles.

ALNY is growing revenue faster at 96.4% — sustainability is the question.

ALNY generates stronger free cash flow (49M), providing more financial flexibility.

Monitor BIOTECHNOLOGY industry trends, competitive dynamics, and regulatory changes.

Bottom Line

ALNY scores higher overall (65/100 vs 20/100) and 96.4% revenue growth. Both earn "Strong Buy" and "Avoid" ratings respectively — the choice depends on your investment horizon and risk tolerance.

This analysis is generated from publicly available financial data. Not financial advice.

Actuate Therapeutics, Inc. Common stock

HEALTHCARE · BIOTECHNOLOGY · USA

Actuate Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to developing innovative therapies for serious diseases, with a particular emphasis on oncology. The company is advancing its proprietary drug candidates through rigorous clinical trials to tackle significant unmet medical needs and improve patient outcomes. By cultivating a robust pipeline focused on transformative therapeutic solutions, Actuate aims to drive strategic growth and deliver substantial value to its investors, reinforcing its competitive stance within the biotechnology sector.

Alnylam Pharmaceuticals Inc

HEALTHCARE · BIOTECHNOLOGY · USA

Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing and commercializing RNA interference (RNAi) therapies. The company is headquartered in Cambridge, Massachusetts.

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