WallStSmart

AstraZeneca PLC (AZN)vsOpus Genetics, Inc. (IRD)

VS

Smart Verdict

WallStSmart Research — data-driven comparison

AstraZeneca PLC generates 504273% more annual revenue ($60.44B vs $11.98M). AZN leads profitability with a 17.2% profit margin vs 0.0%. AZN earns a higher WallStSmart Score of 64/100 (C+).

AZN

Buy

64

out of 100

Grade: C+

Growth: 6.0Profit: 8.5Value: 6.0Quality: 5.0
Piotroski: 6/9Altman Z: 1.48

IRD

Avoid

19

out of 100

Grade: F

Growth: 2.7Profit: 2.5Value: 6.7Quality: 6.5
Piotroski: 3/9Altman Z: -6.86
IV

Intrinsic Value Comparison

Multi-model valuation · Graham Formula

AZNUndervalued (+5.9%)

Margin of Safety

+5.9%

Fair Value

$194.57

Current Price

$189.62

$4.95 discount

UndervaluedFair: $194.57Overvalued
IRDUndervalued (+45.1%)

Margin of Safety

+45.1%

Fair Value

$5.99

Current Price

$4.18

$1.81 discount

UndervaluedFair: $5.99Overvalued

Key Strengths & Concerns

Side-by-side fundamental analysis

Key Strengths

AZN4 strengths · Avg: 8.8/10
Market CapQuality
$284.30B10/10

Mega-cap, among the largest globally

Return on EquityProfitability
21.9%9/10

Every $100 of equity generates 22 in profit

Operating MarginProfitability
27.9%8/10

Strong operational efficiency at 27.9%

Free Cash FlowQuality
$1.82B8/10

Generating 1.8B in free cash flow

IRD1 strengths · Avg: 10.0/10
Debt/EquityHealth
-0.5710/10

Conservative balance sheet, low leverage

Areas to Watch

AZN2 concerns · Avg: 3.0/10
P/E RatioValuation
27.6x4/10

Moderate valuation

Altman Z-ScoreHealth
1.482/10

Distress zone — elevated risk

IRD4 concerns · Avg: 3.3/10
EPS GrowthGrowth
0.0%4/10

0.0% earnings growth

Market CapQuality
$339.35M3/10

Smaller company, higher risk/reward

Profit MarginProfitability
0.0%3/10

0.0% margin — thin

Piotroski F-ScoreQuality
3/93/10

Weak financial health signals

Comparative Analysis Report

WallStSmart Research

Bull Case : AZN

The strongest argument for AZN centers on Market Cap, Return on Equity, Operating Margin. Profitability is solid with margins at 17.2% and operating margin at 27.9%. Revenue growth of 12.5% demonstrates continued momentum.

Bull Case : IRD

The strongest argument for IRD centers on Debt/Equity.

Bear Case : AZN

The primary concerns for AZN are P/E Ratio, Altman Z-Score.

Bear Case : IRD

The primary concerns for IRD are EPS Growth, Market Cap, Profit Margin.

Key Dynamics to Monitor

AZN profiles as a mature stock while IRD is a value play — different risk/reward profiles.

IRD carries more volatility with a beta of 0.55 — expect wider price swings.

AZN is growing revenue faster at 12.5% — sustainability is the question.

AZN generates stronger free cash flow (1.8B), providing more financial flexibility.

Bottom Line

AZN scores higher overall (64/100 vs 19/100), backed by strong 17.2% margins and 12.5% revenue growth. IRD offers better value entry with a 45.1% margin of safety. Both earn "Buy" and "Avoid" ratings respectively — the choice depends on your investment horizon and risk tolerance.

This analysis is generated from publicly available financial data. Not financial advice.

AstraZeneca PLC

HEALTHCARE · DRUG MANUFACTURERS - GENERAL · USA

AstraZeneca PLC discovers, develops, manufactures and markets prescription drugs in the areas of oncology, cardiovascular, renal and metabolism, respiratory, infections, neuroscience and gastroenterology worldwide. The company is headquartered in Cambridge, the United Kingdom.

Opus Genetics, Inc.

HEALTHCARE · BIOTECHNOLOGY · USA

Opus Genetics, Inc. (IRD) is a leading biotechnology firm focused on developing innovative gene therapies for rare retinal diseases impacting vision. By leveraging advanced gene-editing technologies and a robust research foundation, Opus aims to fulfill critical unmet medical needs in ocular health. With a promising pipeline supported by active clinical trials and strategic collaborations, the company is well-positioned to make significant contributions to patient care while presenting compelling growth opportunities for institutional investors in the dynamic healthcare landscape.

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